摘要
目的探讨尤瑞克林联合阿替普酶治疗急性脑梗死患者的疗效。方法采用随机数字表法将117例急性脑梗死患者分组，对照组58例采用阿替普酶溶栓治疗，观察组59例联合尤瑞克林治疗。比较两组患者治疗后的临床疗效、不良反应发生率、神经功能、脑血管储备功能（CVR）及生活质量改善情况。结果观察组总有效率（96．61％）高于对照组（84．48％），并发症发生率（8．47％）低于对照组（22．41％，P〈0．05）；观察组治疗后NIHSS评分低于对照组，Barthel指数高于对照组（P〈0．05）；观察组治疗后搏动指数（PI）低于对照组，平均血流速度（MFV）、屏气指数（BHI）及CVR均高于对照组（P〈0．05）。结论在阿替普酶静脉溶栓的基础上，联合应用尤瑞克林，能够进一步提高急性脑卒中的治疗效果，改善患者的神经功能及脑血管储备功能，提高生活质量，降低并发症发生率。
Objective To investigate the efficacy of acerpase combined with urokallikrein on a- cute cerebral infarction. Methods A total of 117 patients with acute cerebral infarction were randomly divided. The 58 cases in control group were treated with thrombolytie therapy with aheplase, and the 59 cases in observation were treated with urokallikrein in addition. The clinical curative effects, adverse re- action rates, neurological function, cerebral vascular reserve function and quality of life were compared. Results The total effective rate of the observation group was 96.61%, which was higher than that （84.48%） in the control group（P 〈 0. 05 ） ; the complication rate of the observation group was 8.47%, which was lower than that of the control group （22.41% , P 〈0.05）. The NIHSS score of the observa- tion group after treatment was lower than that of the control group, Barthel index was higher than that of control group （ P 〈 0. 05 ）. The level of PI of the observation group was lower than that in the control group, and the levels of BHI, MFV and CVR were higher than those of the control group （P 〈 0. 05 ）. Conclusions Based on the intravenous thrombolysis with aheplase, urokallikrein can further improve the therapeutic effect on acute stroke, improve the neurological function and cerebrovascular reserve function and the quality of life and reduce the incidence of complications.
作者
赵凤华
袁方
Zhao Fenghua, Yuan Fang(1.Department of Neurology, Zhumadian Central Hospital, Zhumadian 463000, China; 2.Department of Neurosurgery, Zhumadian Central Hospital, Zhumadian 463000, Chin)
出处
《中国实用医刊》
2018年第8期116-118,共3页
Chinese Journal of Practical Medicine
关键词
阿替普酶
尤瑞克林
急性脑梗死
神经功能
脑血管储备功能
Acerpase
Urokallikrein
Acute cerebral infarction
Nerve function
Cerebral vascular reserve function
