摘要
星形胶质细胞是中枢神经系统中最丰富的细胞,在大脑正常生理过程中扮演重要角色。脑梗死发生后,星形胶质细胞激活成为反应性星形胶质细胞,并形成胶质瘢痕,在脑损伤过程中发挥重要作用。根据其在脑梗死后神经保护、调节瘢痕形成、神经再生、维持血脑屏障和促进血管生成、调节免疫应答等方面的作用,学者们提出了靶向星形胶质细胞的多种治疗策略。本文就反应性星形胶质细胞在脑梗死后发挥的积极作用以及相应的治疗策略作一综述。
Astrocytes are the most abundant cells in the central nervous system and play significant roles in normal brain.With cerebral infarction,astrocytes are activated as reactive astrocytes and form glial scars,which play an essential part in brain injury.According to their roles in neuroprotection after cerebral infarction,regulation of scar formation,nerve regeneration,maintenance of blood-brain barrier,promotion of angiogenesis and immune response,scholars have proposed a variety of therapeutic strategies based on targeting astrocytes.This article reviews the research progress on the changes in astrocyte signaling pathways before and after cerebral infarction and the related therapeutic strategies.
作者
叶建宇
孙自玉
胡薇薇
YE Jianyu;SUN Ziyu;HU Weiwei(College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Department of Pharmacology,School of Basic Medical Sciences,Zhejiang University School of Medicine,Hangzhou 310058,China)
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2018年第5期493-498,共6页
Journal of Zhejiang University(Medical Sciences)
基金
浙江大学第二十期大学生科研训练计划(SRTP)(X20170274)
关键词
脑梗死
星形细胞
瘢痕/病因学
综述
Brain infarction
Astrocytes
Cicatrix/etiology
Review
