摘要
目的分析丁苯酞联合综合干预对脑梗死恢复期患者的治疗效果。方法选择102例脑梗死恢复期患者,随机分为对照组与观察组,各51例。观察组采用前列地尔注射液联合丁苯酞注射液进行治疗,对照组采用前列地尔注射液进行治疗,2组均治疗2周,治疗期间2组均进行综合干预。观察2组治疗2周后临床疗效,比较2组治疗前和治疗2周后血清疾病相关因子水平、血液流变学指标及神经功能量表评分。结果治疗2周后,观察组总有效率(94.12%,48/51)显著高于对照组(80.39%,41/51)(P<0.05)。治疗2周后2组血清神经元特异烯醇化酶(NSE)、N末端脑钠肽前体(NT-ProBNP)、内皮素-1(ET-1)水平、全血红细胞聚集指数、血浆黏度、全血黏度及美国国立卫生研究院卒中量表(NIHSS)评分均降低,观察组低于对照组(P<0.05)。治疗2周后2组Fugl-Meyer量表(FMA)、Barthel指数(BI)评分升高,观察组高于对照组(P<0.05)。结论丁苯酞联合综合干预可改善脑梗死恢复期患者血液流变学、神经功能及运动功能,提高患者生活质量,治疗效果良好。
Objective To analyze the therapeutic effect of butylphthalide combined with a comprehensive intervention on patients with cerebral infarction in the convalescent period.Methods A total of 102 patients with cerebral infarction in the convalescent period were selected and randomly divided into a control group and an observation group,with 51 cases in each group.The observation group was treated with the alprostadil injection combined with the butylphthalide injection,while the control group was treated with the alprostadil injection.Both groups were treated for two weeks,and both groups were given a comprehensive intervention during the treatment period.The clinical efficacy of the two groups after 2 weeks of treatment was observed,and the serum disease-related factor levels,hemorheology indexes and neurological function scale scores were compared between the two groups before and after treatment for two weeks.Results After two weeks of treatment,the total effective rate in the observation group(94.12%,48/51)was significantly higher than that in the control group(80.39%,48/51)(P<0.05).After two weeks of treatment,the levels of serum neuron-specific enolase(NSE),N-terminal precursor brain natriuretic peptide(NT-ProBNP),endothelin-1(ET-1),whole blood erythrocyte aggregation indexes,plasma viscosity,whole blood viscosity and National Institutes of Health Stroke Scale(NIHSS)scores were all decreased in the two groups,and the observation group was lower than the control group(P<0.05).After two weeks of treatment,the scores of Fugl-Meyer scale(FMA)and Barthel index(BI)in the two groups were increased,and those in the observation group were higher than those in the control group(P<0.05).Conclusion Butylphthalide combined with the comprehensive intervention can improve the hemorheology,neurological function and motor function of patients with cerebral infarction in the convalescent period,improve their quality of life,with a good therapeutic effect.
作者
康琳
李颖
王希
李美娥
KANG Lin;LI Ying;WANG Xi;LI Meie(Department of Rehabilitation Medicine,Baoding Second Hospital,Baoding 071000,China;Department of Encephalopathy,Xianxian Hospital of Traditional Chinese Medicine,Cangzhou 062250,China)
出处
《长春中医药大学学报》
2022年第4期439-442,共4页
Journal of Changchun University of Chinese Medicine
基金
河北省中医药管理局-2019年度中医药类科研计划项目(2019283)。
关键词
脑梗死
恢复期
丁苯酞
综合干预
血液流变学
神经功能
cerebral infarction
convalescent period
butylphthalide
comprehensive intervention
hemorheology
neurological function
