摘要
目的长链非编码RNA(long non-coding RNA,lncRNA)是指长度>200个核苷酸不编码蛋白质的RNA,近年来研究显示,lncRNA在多种生物体中可作为癌基因或抑癌基因,对肿瘤的发生发展起着重要作用。本研究探讨lncRNA在妇科恶性肿瘤中的研究进展,以及lncRNA在妇科恶性肿瘤发生发展中的作用,为妇科恶性肿瘤早期发现及靶向治疗提供方向。方法应用PubMed和CNKI期刊全文检索系统,以"长链非编码RNA、卵巢癌、宫颈癌、子宫内膜癌、绒毛膜癌和外阴癌"为关键词,检索2005-2017年相关文献。共检索到中文文献115篇,英文文献347篇。纳入标准:lncRNA在妇科恶性肿瘤相关性的科学研究。根据纳入标准分析文献48篇。结果通过lncRNA表达谱和lncRNA的功能性研究的相关文献回顾性分析,发现多种lncRNA在卵巢癌、宫颈癌和子宫内膜癌等不同妇科恶性肿瘤中存在异常表达,同时总结了不同lncRNA参与妇科肿瘤发生发展的作用机制。结论 lncRNA在妇科恶性肿瘤领域的研究取得丰硕成果,为妇科各种恶性肿瘤的诊断和治疗提供了方向。
OBJECTIVE Long non-coding RNAs（lncRNA）are generally defined as RNA molecules greater than200 nt in length and without protein-coding property,in recent years many researches showed that lncRNA could act as oncogene or tumor suppressor gene in many creatures,which regulated the process in tumor.The aim of this study is to summarize the advances of long non-coding RNA（long non-coding RNA,lncRNA）advances in gynecological malignancies,and discuss the critical role of lncRNA in the development of gynecologic malignancies,which shed light on early detection and targeted therapy for gynecological malignancies.METHODS With PubMed and CNKI Journal full-text retrieval system,we retrieved and analyzied 48 literatures from a total of 115 Chinese and 347 English literature,using＂long non-coding RNA,ovarian cancer,cervical cancer,endometrial cancer,choriocarcinoma,vulva cancer＂as keywords,from2005 to 2017.Enrollment criteria：lncRNA associated researches in gynecologic malignancies.RESULTS Through the retrospective analysis of the literature of the expression profile and functional analyses of lncRNAs,we found that several abnormal expression have been shown to be deregulated in ovarian cancer,cervical cancer,endometrial cancer and other different gynecological malignant tumor.At the same time,the mechanism of different lncRNA involved in the pathogenesis and development of gynecologic cancer was summarized.CONCLUSION The researches of lncRNA in gynecologic malignancies are prolific and put forward novel insights in the diagnosis and treatment in the future.
作者
鲁艳明
黄翠艳
王月
周梦雅
LU Yan-ming;HUANG Cui-yan;WANG Yue;ZHOU Meng-ya(Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical Universit , Shenyang 110004, P. R. China)
出处
《中华肿瘤防治杂志》
CAS
北大核心
2017年第24期1751-1756,共6页
Chinese Journal of Cancer Prevention and Treatment
基金
国家自然科学基金(81001163)
沈阳市科技厅基金(F13-220-9-46)
2015辽宁省自然课题(2015020462)
关键词
长链非编码RNA
卵巢癌
宫颈癌
子宫内膜癌
外阴癌
妇科恶性肿瘤
long non-coding RNA
ovarian cancer
cervical cancer
endometriat cancer
vulva cancer
gynecological malignancies
