摘要
目的探讨早期T2DM患者血浆B型钠尿肽前体(NT-proBNP)与颈动脉内-中膜厚度(CIMT)的关系。方法依据CIMT值将120例早期T2DM患者分为CIMT正常(NCIMT,n=47)组、CIMT增厚(TCIMT,n=42)组和颈动脉斑块(CAP,n=31)组,另选同期门诊健康体检者30名为正常对照(NC)组,检测一般临床指标、生化指标及NT-proBNP,研究各项指标间的关系。结果随着CIMT逐渐增厚,NCIMT组、TCIMT组和CAP组NT-proBNP水平依次升高[(239.77±76.30)vs(371.80±73.61)vs(405.63±80.91)pg/ml,P<0.05]。NT-proBNP水平与SUA呈正相关,与HbA_1c呈负相关(r=0.53,P<0.01;r=-0.22,P<0.05)。偏相关分析显示,校正年龄、SUA影响后,CIMT仍与NTproBNP水平相关(r=0.37,P<0.01)。结论 NT-proBNP可作为T2DM患者早期大血管病变的生物指标。
Objective To investigate the relationship between plasma N-terminal pro brain natriuretic peptide（NT-proBNP） and carotid artery intima-media thickness（CIMT）in patients with early type 2 diabetes mellitus（T2DM）. Methods 120 patients with newly diagnosed type 2 diabetes mellitus were divided into carotid intima normal group （NCIMT）, carotid intima thickening group （TCIMT） and carotid atherosclerotic plaque group （CAP）. Clinical index, laboratory index and concentration of plasma NT-proBNP were examined. The relationship among various indexes was analyzed. Results The level of NT-proBNP increased in T2DM patients with the increase of the severity of CIMT thickening[（239.77± 76.30） vs （371.80 ± 73.61） vs （405.63 ± 80.91） pg/ml, P〈0.05]. The levels of NT-proBNP were positively correlated with SUA（r= 0.53 ,P〈0. 01） and negatively correlated with HbA1 c（r=-0. 22, P〈 0. 05）. Partial correlation analysis suggested that CIMT was still related with NT-proBNP level after adjustment for age and uric acid （r=0.37,P〈0. 01）. Conclusion NT-proBNP could be a marker for early detection of macro-vascular complication in T2DM patients.
作者
肖丽红
周玉
黄秋菊
赖璐华
XIAO Lihong;ZHOU Yu;HUANG Qiuju;et al.(Department of Endocrinology, The People＇ s Hospital of Liuzhou , Liuzhou 545006, Chin)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2018年第4期301-303,共3页
Chinese Journal of Diabetes
基金
广西壮族自治区卫计委自筹经费科研课题(Z2007311)
关键词
糖尿病
2型
B型钠尿肽前体
颈动脉内-中膜厚度
Diabetes mellitus, type 2
N-terminal pro brain natriuretic peptide
Carotid artery intima-media thickness
