摘要
近年来人们认识到异常表观遗传修饰与B细胞淋巴瘤的发生发展密切相关。表观遗传学是研究DNA序列不改变的情况下基因表达和功能发生遗传性改变的一门学科,主要包括DNA甲基化、组蛋白修饰、mi RNA等,其中组蛋白修饰是最重要的表观遗传修饰。研究表明,组蛋白修饰异常是B细胞淋巴瘤重要的发病机理,尤其是研究较为深入的组蛋白甲基化及乙酰化异常。同时,还可以通过改变表观遗传修饰达到治疗肿瘤的目的,这成为当前一大研究的热点。因此,本文主要从组蛋白修饰控制生发中心B细胞发育和组蛋白修饰酶突变这2个方面对B细胞淋巴瘤发病机制进行研究,并讨论对应表观遗传治疗。
It has been increasingly recognized that the pathogenesis of B-cell lymphoma closely relates to the epigenetic disregulations. Epigenetics is a subdiscipline, which means heritable changes in gene expressions without alterations in the DNA sequence, and the DNA methylation, histone modification and miRNA maily were involved. Histone modification is the most important epigenetic modification, the researches showed that the aberrant histone modification is the important pathogenesis in B-cell lymphoma, especially the aberrant histone methylation and acetylation. In the meantime, the tumor can be treated by changing the epigenetic modification, which become a research hotpoint. This review summarizes the pathogenesis of B cell lymphoma and discusses the epigenetic treatment of B cell lymphoma mainly in terms of histone modification regulation for B cell development in the germinal center and mutation of histone madification enzymes.
作者
张姣
潘云
李艳
ZHANG Jiao1 PAN Yun2 LI Yan1(l Department of Pathology, Basic Medical College of Dali University, Dali 671000, Yunnan Province, China ; 2 Department of Pathology, The Affiliated Hospital of Dali University, Dali 671000, Yunnan Province, Chin)
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2018年第2期615-620,共6页
Journal of Experimental Hematology
