摘要
血液肿瘤亦称恶性血液病,包括急/慢性白血病、淋巴瘤、多发性骨髓瘤以及骨髓增殖性疾病等,是严重威胁人类生命健康的恶性疾病。近年来,随着表观遗传学在医学研究中的兴起,很多学者通过对表观遗传学作用机制的深入探究发现血液肿瘤的新治疗靶点,并研发出相应的药物,揭示了表观遗传修饰机制的紊乱,或将成为血液肿瘤临床诊断、靶向治疗与预后评估的新方向。本文就表观遗传调控与血液肿瘤的关系、表观遗传学靶向治疗在恶性血液病中的研究进展予以综述。
Hematological tumors,also known as neoplastic diseases of blood,include acute/chronic leukemia,lymphoma,multiple myeloma,and myeloproliferative diseases.They are malignant diseases that seriously threaten human health.In recent years,as epigenetics has become one of the research hotspots in medicine,many scholars have discovered new therapeutic targets for hematological tumors through exploring the epigenetics mechanism and developed corresponding drugs.It reveals that the alteration in epigenetic modification will become a new direction for clinical diagnosis,targeted therapy and prognosis evaluation of hematological tumors.This article reviews the research advances in relationship between epigenetic regulation and hematological tumors,and the application of epigenetic targeted therapy in hematologic malignancies.
作者
刘彦权
沈建箴
周华蓉
LIU Yanquan;SHEN Jianzhen;ZHOU Huarong(Department of Hematology,Fujian Institute of Hematology,Fujian Provincial Key Laboratory of Hematology,Fujian Medical University Union Hospital,Fuzhou 350001,Fujian Province,China)
出处
《解放军医学院学报》
CAS
2019年第11期1101-1105,共5页
Academic Journal of Chinese PLA Medical School
基金
国家自然科学基金(81800167)
福建省自然科学基金项目(2017J05132)
福建省卫生厅中青年骨干人才培养项目(2018-ZQN-40)
福建医科大学启航基金项目(2016QH020)
福建省血液医学中心建设项目(闽卫医政[2017]171号)
国家及福建省临床重点专科建设项目(闽卫医函[2011]1018号、闽卫科教[2012]149号).
关键词
表观遗传学
血液肿瘤
靶向治疗
epigenetics
hematologic neoplasms
targeted therapy
