摘要
目的系统评价磁控胶囊胃镜(magnetically controlled capsule gastroscopy,MCCG)和传统胃镜在胃部疾病中的检出率、不良反应及检出时间等方面的差异。方法检索Pub Med、Cochrane library、Medline、维普中文科技期刊数据库、中国知网(CNKI)、万方数据资源库和中国生物医学文献数据库等数据库,检索时间截至2017年11月。按照QUADAS量表进行质量评价。从文献中提取阳性检出率、检查时间和不良事件发生情况等信息,用Rev Man5.3和Meta-disc1.4进行数据分析、森林图及SROC曲线绘制。结果从检出的254篇文献中删除重复文献、提取对比研究MCCG和传统胃镜的临床试验,排除样本重叠的试验,最终纳入9项研究,共626例患者。纳入检出率研究的4个试验结果汇总敏感度为0.94(95%CI 0.9~0.97),汇总特异度为0.73(95%CI 0.51~0.89),汇总的阳性似然比为3.1(95%CI 1.65~5.38),汇总的阴性似然比为0.09(95%CI 0.04~0.21),汇总曲线下面积(area under the curve,AUG)为0.9718,Q值0.9228。MCCG和传统胃镜对不同病变的检出情况差异无统计学意义。另外,行MCCG检查时病人发生的不良反应、疼痛和不适均少于传统胃镜。而MCCG的检查时间明显高于传统胃镜。结论磁控胶囊内镜和传统胃镜在检出率上差异无统计学意义,磁控胶囊检查所需时间长,不良反应少,可为老人、儿童及不适合传统胃镜检查者提供便利。
Objective This study aims to evaluate the difference between Magnetically Controlled Capsule Gastroscopy and Traditional Gastroscopy in the detectability of gastric diseases, adverse events and examination time. Methods Articles related to the Magnetically Controlled Capsule Gastroscop）5 published until November 2017, were retrievaled in the databases including PubMed, Cochrane library, Medline, VIP Chinese Science and Technology Periodical Database, China Knowledge Source Database （CNKI）, Wanfang Data Resource Library and China Biomedical Literature Database.We evaluated articles based on QUADAS scale and extracted data including positive detection rate, examination time and adverse events. RevManS.3 software and Meta-discl.4 software were applied for data analysis, forest map and SROC curve presentation. Results After deleting duplicate articles and searching trials about MCCG and traditional gastroscopy3 9 studies with 626 patients were retained for analysis. Four studies were brought into detection rate analysis. The pooled sensitivity was 0.94 （95%CI： 0.9-0.97）, pooled specificity was 0.73（95%Ch 0.51-0.89）, positive likelihood ratio was 3.1 （95%Ch 1.65-5.38）, negative likelihood ratio was 0.09（95%Ch 0.04-0.21）and the SROC area under the curve （AUG） was 0.9718, 0,=0.9228. No statistical difference existed between Magnetically controlled Capsule Gastroscopy and Traditional Gastroscopy in detectability of gastric diseases. Inaddition, less patients reported adverse events, pain and discomfort during MCCG examination. However, the examination time of MCCG was significantly longer than that of conventional gastroscopy. Conclution Compared with conventional gastroscopy, Magnetically controlled Capsule Gastroscopy is a promising modality for gastric examination with comparable detability of gastric diseases and lower sdverse events.
作者
朱佳慧
陈文晓
茹楠
钱阳阳
廖专
李兆申
ZHU Jia-hui;CHEN Wen-xiao;RU Nan;QIAN Yang-yang;LIAO Zhuan;LI Zhao-shen(Department of Gastroenterology, Changhai Hospital Affiliated to the Naval Military Medical University, Shanghai 200433, Chin)
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2018年第4期358-363,共6页
Chinese Journal of Practical Internal Medicine
关键词
磁控胶囊胃镜
传统胃镜
META分析
灵敏度和特异度
不良反应
检查时间
magnetically controlled capsule gastroscopy
traditional gastroscopy
meta analysis
sensitivity and specificity
adverse reactions
examination time
