摘要
目的：探讨健脾益胃化痰法对慢性阻塞性肺疾病（COPD）急性加重期呼吸衰竭机械通气患者的免疫功能和脱机成功率的影响。方法：选取2013年1月-2016年12月医院收治的COPD急性加重期伴呼吸衰竭的患者96例为研究对象，随机分为治疗组与对照组，两组患者均行机械通气治疗及常规的西医治疗，治疗组患者在此基础上给予健脾益胃化痰法治疗，治疗结束后对两组患者的中医证候疗效及脱机成功率进行对比，并对比治疗前后两组患者的中医证候积分及免疫功能相关指标变化。结果：治疗组患者的总有效率显著高于对照组（P〈0．05）；治疗组患者的成功脱机率显著高于对照组（P〈0．05）；治疗前，两组患者的中医证候积分对比无显著差异（P〉0．05），治疗后，治疗组与对照组患者咳痰、咳嗽、胸闷、喘息中医证候积分均明显较治疗前降低（P〈0．05），且治疗组各证候积分较对照组降低程度更显著（P〈0．05）；治疗前，两组患者的免疫功能指标对比无显著差异（P〉0．05），治疗后，治疗组与对照组患者的IgA、IgG、IgM、CD4＋、CD3＋、CD4＋／CD8＋均较治疗前升高，CD8较治疗前降低（P〈0．05），且治疗后治疗组各免疫指标改善程度显著优于对照组（P〈0．05）。结论：健脾益胃化痰法辅助治疗COPD急性加重期呼吸衰竭机械通气患者疗效显著，可有效提高患者的免疫功能和脱机成功率，值得临床推广。
Objective： To investigate the strengthening spleen and stomach and resolving phlegm method on chronic obstructive pulmonary disease （COPD） affecting the success rate and immune function of mechanical ventilation for acute exacerbation of respiratory failure patients. Methods ：From January 2014 -December 2016 in our hospital,96 cases of acute exacerbation of COPD patients with respiratory failure as the research objects, were randomly divided into treatment group and control group. Two groups were treated with mechanical ventilation and conventional western medicine treatment. The patients in the treatment group were given the strengthening spleen and stomach and resolving phlegm treatment. The effect of TCM and the offline success rate of two groups as well as related indicators of TCM syndrome score and immune function of patients in two groups were compared and analyzed before and after treatment. Results ： The total effective rate of treatment group was significantly higher than the control group＇ s （ P 〈 0. 05 ）. The treatment group＇ s success rate was significantly higher than that of the control group （P 〈 0. 05 ）. Before treatment, there was no significant difference of the TCM syndrome scores between the two groups（ P 〉 0. 05 ）. After treatment, the treatment group and the control group＇ s sputum, cough, chest tightness and TCM wheezing scores were significantly lower than those before treatment （ P 〈 0. 05 ）, and the treatment group＇ s symptom scores decreased more significantly than those of the control group （ P 〈 0. 05 ）. Before treatment, there was no significant difference between the two groups＇ immune function index （ P 〉 0. 05）. After treatment, the treatment group and the control group＇ s IgA, IgG, IgM, CD4＋ , CD3＋ and CD4＋/CD8＋ were higher than those before treatment, and CDs was lower than that before treatment （P 〈 0. 05）. The improvement of im- mune index in the treatment group was significantly better than that in the c
作者
温敏勇
赵馥
徐运升
夏欣田
杨柳柳
WEN Minyong;ZHAO Fu;XU Yunsheng;XIA Xintian;YANG Liuliu(Intensive Medicine,The First Affiliated Hospital of Guangzhou University of Chinese Mediciae , Guangzhou 510405, Guangdong, China;Respiratory,The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China)
出处
《中华中医药学刊》
CAS
北大核心
2018年第4期920-922,共3页
Chinese Archives of Traditional Chinese Medicine
基金
广东省省级科技计划项目(2014A020209074)
关键词
慢性阻塞性肺疾病
急性加重期
呼吸衰竭
健脾益胃法
机械通气
chronic obstructive pulmonary disease
acute exacerbation
respiratory failure
strengthening spleen and stomach and resolving phlegm method
mechanical ventilation
