摘要
目的:观察中药复方合剂金黄1号对SARS疑似患者免疫功能的影响。方法:采取金黄1号治疗前后SARS疑似患者全血及血清,测定T淋巴细胞亚群、机体免疫球蛋白含量、补体成分,白细胞介素2、6、10(IL-2、IL-6、IL-10),干扰素-γ(IFN-γ)、IFN-α、肿瘤坏死因子(TNF-α)。结果:金黄1号可显著减少SARS疑似患者T细胞亚群下降的幅度(P<0.05),促进了恢复期T细胞亚群的回升。服药前及服药后10、20d机体免疫球蛋白、补体成分含量差异均无统计学意义。13名患者服药后血清IL-2、IFN-γ均升高,与服药前比较差异有统计学意义(P<0.01)。服药前后血清IL-10比较差异无统计学意义(P>0.05)。结论:金黄1号能显著提高SARS疑似患者IL-2、IFN-γ产生水平,促进T细胞免疫功能的恢复。
Objective： To observe the variation in the immune function of the suspected SARS patients treated with traditional Chinese medicine JinHuang-1. Methods：Before and after treatment with JinHuang- 1, the SARS patient＇s peripheral IL-2, IL-6, IL-10, IFN-γ, IFN-α concentrations and T lymphocyte subpopulations and quantity of immunoglobulin and complement were detected. Result：The treatment of suspected SARS patients with JinHuang-1. Compared with the situation before treatment,a total of 13 patients＇ peripheral IL-2 and IFN-α concentrations increased significantly after receiving treatment （ P〈0.01）. There wasn＇t a significant difference in peripheral IL-10 concentration before and after treatment（ P〉0.05 ）. Conclusion ： Treatment with JinHuang-1 can significantly increase the production of IL-2 and IFN-αin suspected SARS patients and promote the recovery of T lymphocyte immunity.
出处
《广西医科大学学报》
CAS
北大核心
2005年第4期514-516,共3页
Journal of Guangxi Medical University
基金
广西科学研究与技术开发计划项目资助(桂科攻0332007)
