摘要
目的探讨宫颈癌患者血清人附睾蛋白4(HE4)的表达及临床意义。方法选取2010年7月至2012年8月间苏州大学附属第二医院收治的63例宫颈癌患者(宫颈癌组)、47例宫颈上皮内瘤变患者(良性对照组)和35例健康女性(健康对照组)为研究对象,采用酶联免疫吸附法检测血清HE4水平。比较各组受试者血清HE4水平,分析血清HE4水平与宫颈癌患者的病理特征关系,以良性对照组和健康对照组为参照评价血清HE4对宫颈癌的诊断价值,并分析HE4水平与预后生存期的关系。结果宫颈癌组患者血清HE4水平高于良性对照组和健康对照组,差异均有统计学意义(均P<0.05);良性对照组与健康对照组比较,差异无统计学意义(P>0.05)。血清HE4水平与宫颈癌患者的病理类型及肿瘤直径无关,差异无统计学意义(P>0.05),与患者年龄、月经状态、分化程度、FIGO分期、浸润深度及淋巴结转移有关,差异均有统计学意义(均P<0.05)。血清HE4诊断宫颈癌的AUC值为0.70,当约登指数最大时,敏感性为53.6%,特异性为82.7%,准确性为56.4%。高HE4组平均生存时间短于低HE4组,差异有统计学意义(P<0.05)。结论宫颈癌患者血清HE4处于高水平表达状态,检测血清HE4水平有助于宫颈癌的鉴别诊断、病情监测及预后评估。
Objective To explore the expression of human epididymis protein 4（HE4） in patients with cervical carcinoma and its clinical significance. Methods Sixty-three patients with cervical cancer（cervical cancer group）,47 patients with cervical intraepithelial neoplasia（benign control group） who were treated and 35 healthy women who had physical examined（healthy control group） at The Second Affiliated Hospital of Soochow University from July 2010 to August 2012 were selected as the research subjects. Serum HE4 levels were detected by enzyme linked immunosorbent assay. Differences in the serum levels of HE4 in each group were compared,and the relationship between the level of serum HE4 and the pathological characteristics of cervical cancer patients was analyzed. The diagnostic value of serum HE4 for cervical cancer was discussed comparing with the healthy control group and healthy control group and the relationship between HE4 level and prognosis and survival time was analyzed. Results The level of serum HE4 was higher in the cervical cancer group than in the benign control group and the healthy control group（all P〈0. 05）but there was no significant difference between the benign control group and the healthy control group（P〉0. 05）. Serum HE4 levels were independent of the pathological type and tumor diameter（P〉0. 05） and it was associated with age,menstrual status,differentiation degree,FIGO stage,invasion depth and lymph node metastasis in patients with cervical cancer（P〈0. 05）. The AUC value of serum HE4 in the diagnosis of cervical cancer was 0. 70. When the Jorden index was the largest,the sensitivity was 53. 6%,the specificity was 82. 7% and the accuracy was 56. 4%. The average survival time is shorter in the high HE4 group than the low HE4 group（P〈0. 05）. Conclusion The expression level of serum HE4 is high in patients with cervical cancer and detection of serum HE4 level is helpful for differential diagnosis,disease monitoring and prognosis evaluation of cervical cance
作者
邓冰彬
严檬洁
陈瑶
DENG Bing-bin1, YAN Meng-jie2, CHEN Yao3(1. Department of Radiotherapy, The Second Affiliated Hospital of Sooehow University, Suzhou 215000, China; 2. Department of Gynaecology and Obstetrics, Nanjing First Hospital, Nanjing 210001, China; 3. Department of Gynaecology and Obstetrics,The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000 ,Chin)
出处
《中国肿瘤临床与康复》
2018年第3期273-277,共5页
Chinese Journal of Clinical Oncology and Rehabilitation
基金
江苏省卫生厅科研资助项目(Z201305)
关键词
宫颈肿瘤
宫颈上皮内瘤变
人附睾蛋白4
病理特征
诊断价值
Cervical neoplasms
Cervical intraepithelial neoplasias
Human epididymis pro-tein 4
Pathological characteristics
Diagnostic value
