摘要
目的分析单核细胞/高密度脂蛋白胆固醇比值在糖尿病肾病患者中的临床意义。方法收集2015年1月‐2016年11月该院诊治的Ⅱ型糖尿病患者87例为研究对象,依据24-hour尿白蛋白排泄量(UAE)将其分为正常组(22例,<30 mg)、微量组(27例,30~300 mg)和大量组(38例,>300 mg)。统计学分析3组患者临床病理学参数的差异及单核细胞/高密度脂蛋白胆固醇比值与临床病理参数之间的相关性。结果 3组患者血清肌酐水平、24 h尿白蛋白排泄量和单核细胞/高密度脂蛋白胆固醇比值比较差异均有统计学意义(P<0.01);87例Ⅱ型糖尿病患者单核细胞/高密度脂蛋白胆固醇比值与24 h尿白蛋白排泄量呈正相关(r=0.397,P<0.0001);87例Ⅱ型糖尿病患者单核细胞/高密度脂蛋白胆固醇比值与肾小球滤过率呈负相关(r=-0.250,P=0.0196)。结论单核细胞/高密度脂蛋白胆固醇比值可用于评估糖尿病早期肾损伤,对于Ⅱ型糖尿病合并肾病患者具有预后价值。
[Objective] To investigate the clinical significance of monocyte/high density lipoprotein cholesterol ratio （MHR） in type Ⅱ diabetes mellitus patients with nephropathy. [Methods] Eighty-seven type II diabetes mellitus patients hospitalized from January 2015 to November 2016 were included in this study. According to the amount of urinary albumin excretion during 24 hour （24-hour UAE）, patients were divided into three groups： normoalbuminuria group （22 patients, 〈30 mg）, microalbuminuria group （27 patients, 30-300mg）, macroalbuminuria group （38 patients, 〉300 mg）. Differences of clinicopathological parameters in three groups and the relationships between clinicopathological parameters and MHR were statistically analyzed. [Results] Serum creatinine （P =0.006）, 24-hour UAE （P 〈0.001）, and MHR （P =0.003） were all significantly different among the three groups. In 87 patients of type II diabetes mellitus with nephropathy MHR was positively correlated with 24-hour UAE （r = 0.397, P 〈0.0001） and negatively correlated with glomerular filtration rate （GFR） （r =-0.250, P = 0.0196）. [Conclusion] MHR can be used to evaluate the renal iniurv and is a useful early prognostic marker in diabetic nephropathy patients.
作者
宋小五
SONG Xiaowu(Department of Endocrinology, People＇s Hospital of Queshan County, Zhuma, Henan 463200, Chin)
出处
《中国医学工程》
2018年第1期8-12,共5页
China Medical Engineering
关键词
白蛋白尿
糖尿病肾病
糖尿病
单核细胞
高密度脂蛋白
albuminuria
diabetic nephropathy
diabetes mellitus
monocyte
high density lipoprotein
