摘要
目的探讨中医药食综合辨证调控T2DM的有效性和安全性。方法前瞻性观察性临床研究。对符合入选标准的2021年9月-2022年8月北京和为中医院中医科147例T2DM受试者进行自身前后的对照研究。受试者在饮食和运动干预基础上,接受120 d的中医辨证药食综合调理方案的治疗和观察。分别于治疗前后进行主要结局指标[中医症状评分、空腹血糖(FPG)、2 hPG、HbA1c;空腹胰岛素(FINS);C肽],次要结局指标[血脂(TC、TG、HDL-C、LDL-C),血压]及安全性指标的检测。结果与治疗前比较,受试者治疗后FPG[(7.05±1.23)mmol/L比(8.75±2.26)mmol/L]、2 hPG[(7.07±0.78)mmol/L比(10.75±3.01)mmol/L]、HbA1c[(5.49±0.63)%比(6.82±1.47)%]、FINS[(8.82±7.28)μIU/ml比(15.4±9.33)μIU/ml]、C肽[(1.72±1.53)nmol/L比(1.95±0.91)nmol/L]及SBP[(125.79±7.57)mmHg比(137.51±17.94)mmHg]、DBP[(77.54±6.21)mmHg比(82.85±9.65)mmHg]、TG[(1.25±1.24)mmol/L比(1.57±1.04)mmol/L]水平降低(P<0.05);HDL-C[(1.66±0.46)mmol/L比(1.48±0.41)mmol/L]水平升高(P<0.05)。结论中医辨证药食综合调理可有效降低T2DM受试者FPG、2 hPG、HbA1c、FINS、C肽水平,改善血压、血脂水平,且安全性良好。
Objective To explore the effectiveness and safety of comprehensive treatment of type 2 diabetes mellitus(T2DM)based on syndrome differentiation and diet.Methods Prospective clinical study.A total of 147 patients with T2DM from September 2021 to August 2022 who met the inclusion criteria were included in the self-controlled trial.On the basis of diet and exercise intervention,the subjects were treated and observed with comprehensive treatment based on syndrome differentiation for 120 days.The main outcome indicators including TCM symptom score,fasting blood glucose(FPG),2 hPG,HbA1c,Fasting insulin(FINS),C-peptide(C-PR),and the secondary outcome indicators including blood lipid(TC,TG,HDL-C,LDL-C),blood pressure,and safety indicators were performed before and after treatment.Results After treatment,the FPG of subjects decreased from(8.75±2.26)mmol/L to(7.05±1.23)mmol/L,2 hPG decreased from(10.75±3.01)mmol/L to(7.07±0.78)mmol/L,HbA1c decreased from(6.82±1.47)%to(5.49±0.63)%,and FINS decreased from(15.4±9.33)μIU/ml to(8.82±7.28)μIU/ml,C-PR decreases from(1.95±0.91)nmol/L to(1.72±1.53)nmol/L,SBP decreased from(137.51±17.94)mmHg to(125.79±7.57)mmHg,DBP decreased from(82.85±9.65)mmHg to(77.54±6.21)mmHg,TG decreased from(1.57±1.04)mmol/L to(1.25±1.24)mmol/L,HDL-C increased from(1.48±0.41)mmol/L to(1.66±0.46)mmol/L.The above differences were statistically significant(P<0.05).Conclusion The comprehensive treatment of T2DM based on syndrome differentiation and diet can significantly reduce the blood glucose indicators including FPG,2 hPG,HbA1c,FINS and C-PR,and benefit blood pressure and blood lipids with no adverse reactions.
作者
程华
宋亚南
周金国
鲁野
刘铜华
吴丽丽
兰为民
Cheng Hua;Song Yanan;Zhou Jinguo;Lu Ye;Liu Tonghua;Wu Lili;Lan Weimin(Department of Traditional Chinese Medicine,Beijing Hewei Hospital of Traditional Chinese Medicine,Beijing 100057,China;Institute of Health Maintenance of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《国际中医中药杂志》
2023年第4期404-409,共6页
International Journal of Traditional Chinese Medicine
基金
中医养生学教育部重点实验室开放课题(2021HWZYY01)。
关键词
2型糖尿病
血糖
胰岛素抵抗
辨证论治
中医辨证药食调理
Type 2 diabetes mellitus
Blood sugar
Insulin resistance
Treatment based on syndrome differentiation
The comprehensive treatment based on syndrome differentiation and diet
