摘要
目的:观察加味五子衍宗汤治疗男性不育症的临床疗效,以及对精液质量和线粒体功能的影响。方法:将164例男性不育症患者按随机数字表法分为对照组78例和观察组86例。对照组使用左卡尼汀治疗,观察组在对照组治疗的基础上联合加味五子衍宗汤治疗,具体用药如下:菟丝子30 g,五味子20 g,枸杞子20 g,车前子15 g,覆盆子15g。辨证加减:气滞血瘀者加当归15 g,党参20g;肾气不足者加淫羊藿20 g,肉苁蓉15 g,山萸肉10 g,黄芪10 g,水煎300 m L,每天1剂。两组患者均连续治疗3个月。观察两组患者精液量、精子浓度、a+b级精子和a级精子比例、精子线粒体膜电位(mitochondrial membrane potential,MMP)、精子线粒体琥珀酸脱氢酶(succinate dehydrogenase,SDH)的变化,并进行中医证候评分,并评价临床疗效。结果:两组患者临床疗效比较,观察组有效率为77.91%,对照组有效率为62.82%,差异有统计学意义(P<0.05)。两组患者中医证候评分比较,观察组治疗前为(17.27±2.18)分,治疗后为(6.24±0.79)分;对照组治疗前为(17.12±2.33)分,治疗后为(10.38±1.22)分。两组患者同组治疗前后比较,差异有统计学意义(P<0.05)。治疗后两组患者比较,差异有统计学意义(P<0.05)。两组患者精子质量比较,精液量观察组治疗前为(2.45±0.80)m L,治疗后为(3.42±1.26)m L;对照组治疗前为(2.36±0.84)m L,治疗后为(2.87±0.98)m L。同组治疗后比较,差异有统计学意义(P<0.05)。治疗后两组患者比较,差异有统计学意义(P<0.05)。精子浓度观察组治疗前为(29.63±10.94)×106m L^(-1),治疗后为(61.28±18.90)×106m L^(-1);对照组治疗前为(29.44±10.52)×106m L^(-1),治疗后为(53.62±14.58)×106m L^(-1)。同组治疗后比较,差异有统计学意义(P<0.05)。治疗后两组患者比较,差异有统计学意义(P<0.05)。精子活力比较,a+b级精子观察组治疗前为(28.29±9.42)%,治疗后为(56.84±15.30)%;对照组治疗前为(28.16±9.37)%,治�
Objective： To study the effect of modified Wuzi Yanzong Decoction on male infertility and its influence on the quality of semen and the function of mitochondria. Method： 164 male infertility patients in our hospital from March 2015 to January 2017 were randomly divided into a control group of 78 cases and an observation group of 86 cases. The control group was treated with L-carnitine treatment,patients in the observation group was treated with modified Wuzi Yanzong Decoction in addition to that of the control group. The specific usage is as follows： Dodder 30 g,Schisandra 20 g,Medlar 20 g,Plantago 15 g,Raspberry 15 g. Dialectical addition and subtraction： Qi stagnation plus Angelica 15 g,Codonopsis 20 g; Kidney Deficiency plus Epimedium 20 g,Cistanche 15 g,dogwood 10 g,Astragalus 10 g. Both of groups were treated for 3 months. The semen volume,sperm density,sperm a ＋ b and a percentage of sperm,sperm mitochondrial membrane potential（MMP）,sperm mitochondrial succinate dehydrogenase（SDH） score changes and TCM syndrome,and evaluate its efficacy between two groups were observed before and after treatment. Results： The clinical curative effect of the two groups were compared,the effective rate of the observation group was 77. 91%,and the effective rate of the control group was 62. 82%,the difference of which was statistically significant（P 〈0. 05）. The score of TCM syndrome in the two groups was（17. 27 ± 2. 18） points before treatment and（6. 24 ± 0. 79） points after treatment in the observation group,while that was（17. 12 ± 2. 33） points before treatment and（10. 38 ± 1. 22） after treatment points in the observation group. There were significant differences between the two groups both before and after treatment（P 〈0. 05）. After treatment,the difference between the two groups was statistically significant（P 〈0. 05）. The sperm quantity was（2. 45 ± 0. 80） m L before treatment and（3. 42 ± 1. 26） m L after treatment in the observation group,and that was（
作者
李征
曹志华
刘磊
朱清
胡跃世
王阳
LI Zheng;CAO Zhihua;LIU Lei;ZHU Qing;HU Yueshi;WANG Yang(The Central Hospital of Nanyang City)
出处
《中医学报》
CAS
2018年第3期463-467,共5页
Acta Chinese Medicine
基金
国家自然科学基金项目(81360548)
关键词
不育症
精液质量
线粒体膜电位
琥珀酸脱氢酶
加味五子衍宗汤
左卡尼汀
中医药疗法
中西医结合
Infertilitas
semen quality
mitochondrial membrane potential
suecinate dehydrogenase
modified Wuzi Yanzong Decoction
L-carnitine
Chinese medicine therapy
Integrative medicine
