摘要
目的:观察清肺补肾平喘法治疗支气管哮喘的临床疗效及其对支气管哮喘患者免疫功能的影响。方法:96例支气管哮喘患者随机分为对照组和观察组,每组48例。两组均给予抗感染、解痉平喘等基础治疗,对照组在基础治疗的同时给予沙美特罗替卡松粉吸入剂,观察组在对照组治疗基础上给予清肺补肾平喘方。治疗后,比较两组患者临床疗效、中医证候疗效、第1秒用力呼气容积(forced expiratory volume in one second,FEV1)、呼气峰流速值(peak expiratory flow,PEF)以及免疫功能。结果:治疗后,观察组有效率为93.8%,对照组有效率为79.7%,两组有效率比较,差异有统计学意义(P<0.05)。观察组中医证候的有效率为93.8%,对照组为75.0%,两组比较,差异有统计学意义(P<0.05)。与治疗前比较,两组患者FEV1、PEF均显著升高(P<0.05);治疗后,观察组FEV1、PEF显著高于对照组(P<0.05)。与治疗前比较,两组患者CD_4、CD_8、CD_4/CD_8均显著降低(P<0.05);治疗后观察组CD_4、CD_8、CD_4/CD_8显著低于对照组(P<0.05)。结论:清肺补肾平喘法治疗支气管哮喘临床疗效显著,可改善支气管哮喘患者症状、肺功能及免疫功能。
Objective： To observe the clinical curative effect of Qingfei Bushen Pingchuan Therapy on bronchial asthma and its effect on immune function in patients with bronchial asthma. Methods： 96 cases of bronchial asthma patients were randomly divided into control group and observation group of 48 cases. Both groups were given anti-infective,antispasmodic and asthma as well as other basic treatment. The control group was given salmeterol and fluticasone powder inhalation on the basis of the basic treatment,while the observation group was given Qingfei Bushen Pingchuan prescription in addition to that of the control group. After treatment,the clinical efficacy,TCM syndrome efficacy,forced expiratory volume in one second（FEV1）,peak expiratory flow（PEF） and immune function were compared between the two groups. Results： After treatment,the effective rate in the observation group was93. 8% and that in the control group was 79. 7%,the difference was statistically significant（P〈0. 05）. The effective rate of TCM syndromes in the observation group was 93. 8% and that in control group was 75. 0%. There was significant difference between the two groups（P〈0. 05）. Compared with those before treatment,FEV1 and PEF were significantly increased in both groups（P〈0. 05）. After treatment,FEV1 and PEF in observation group were significantly higher than those in control group after treatment（P〈0. 05）. The CD4,CD8andCD4/CD8of the two groups were significantly lower than those before treatment（P〈0. 05）. After treatment,the levels of CD4,CD8andCD4/CD8in the observation group were significantly lower than those in the control group after treatment（P〈0. 05）. Conclusion： The clinical curative effect of Qingfei Bushen Pingchuan Therapy on bronchial asthma is significant,which can improve the symptoms,lung function and immune function in patients.
作者
张英杰
ZHANG Yingjie(The People＇s Hospital Of Zhengzhou City,Zhengzhou Henan China 45000)
出处
《中医学报》
CAS
2018年第3期379-382,共4页
Acta Chinese Medicine
基金
河南省教育厅自然科学研究项目(12A320009)
关键词
清肺补肾平喘法
支气管哮喘
肺功能
第1秒用力呼气容积
呼气峰流速值
免疫功能
中西医结合
Qingfei Bushen Pingchuan Method
Bronchial asthma
Lung function
forced expiratory volume in 1 second
peak ex-piratory flow rate
immune function
Integrative medicine
