摘要
目的：探讨补肾调冲方联合常规西药治疗肾虚血瘀型复发性流产（recurrent spontaneous abortion,RSA）疗效及对患者血清Th1/Th2细胞因子平衡偏移的影响。方法：以西南医科大学附属医院2015年3月—2016年8月收治的122例RSA肾虚血瘀型患者为研究对象,遵循成组序贯设计分为治疗组与对照组,各61例。两组患者同时给予地屈孕酮片,在此基础上,治疗组加服补肾调冲方,待妊娠12周末,对两组患者临床疗效,血清β-绒毛膜促性腺激素（β-human chorionic gonadotropin,β-HCG）,孕酮（progesterone,P）,白细胞介素-2（interleukin-2,IL-2）,白细胞介素-10（interleukin-10,IL-10）,IL-2/IL-10以及血液流变学进行比较。结果：治疗组患者总有效率为91.80%,对照组为80.33%,治疗组优于对照组（P〈0.05）;与治疗前比较,治疗后,两组RSA患者血清β-HCG与P明显升高,且治疗组明显高于对照组（P〈0.05）;与治疗前比较,治疗后,两组RSA患者血清中IL-10水平明显升高,IL-2水平,IL-2/IL-10明显降低,且治疗组明显优于对照组（P〈0.05）;经治疗,两组CPID患者全血高、低切黏度,红细胞聚集指数与红细胞压积均明显降低,且治疗组明显低于对照组（P〈0.05）。结论：补肾调冲方联合常规西药对RSA肾虚血瘀型患者具有积极的治疗效果,可以显著提高患者血清P与β-HCG水平,调节患者Th1/Th2细胞因子平衡,改善微循环障碍,因此值得在临床上推广。
Objective： To study the clinical efficacy of Bushen Tiaochong decoction combined with routine western medicine in treating patients with kidney deficiency and blood stasis type recurrent spontaneous abortion（ RSA）,and its effect on Th1/Th2 cytokines balance. Method： Totally 122 cases of RSA patients treated in our hospital from March 2015 to August 2016 were selected and divided into two groups according to the group sequential design,with 61 cases in clinical group and 61 in control group. Patients in control group were treated with Dydrogesterone tablets; in addition,those in clinical group were also given Gexia Zhunyu decoction. Then the clinical efficacy, β-human chorionic gonadotropin（ β-HCG）, progesterone（ P）, interleukin-2（ IL-2）,interleukin-10（ IL-10）,IL-2/IL-10 and blood rheology were compared. Result： The total effective rate of the control group was 80. 33%,while that of the clinical group was 91. 80%. There was a significant difference（ P 0. 05）. Compared with before treatment,β-HCG increased after treatment（ P 0. 05）. Compared with control group,β-HCG and P of clinical group were higher than those of control group,with statistically significant differences（ P 0. 05）. Compared with before treatment,IL-10 of the two groups after treatment increased,while IL-2 and IL-2/IL-10 decreased（ P 0. 05）. Compared with control group,the value of IL-10 in patients of the experimental group was higher after treatment,while IL-2 and IL-2/IL-10 were lower（ P 0. 05）. After treatment,both groups of CPID patients showed significant reduction in blood viscosity at high/low shear rate,erythrocyte aggregation index and hematocrit,with statistically significant differences（ P 0. 05）. Conclusion： Bushen Tiaochong decoction is very effective in treating RSA. It can significantly improve β-HCG and P,balance Th1/Th2 cytokines and improve microcirculation,thus is worth promotion in clinic.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2018年第5期171-175,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
四川省卫生厅科研项目(120346)
关键词
补肾调冲方
复发性流产
疗效
TH1/TH2细胞因子平衡
血液流变学
Bushen Tiaochong decoction
recurrent spontaneous abortion
clinical efficacy
Th1/Th2 cytokines balance
blood rheology
