摘要
目的:建立利用原子吸收分光光度法测定铁屑及枸橼酸铁铵中有害元素铅,镉,汞,砷,铜,铬的含量,以达到质量控制保证老百姓日常用药安全的目的。方法:铅的测定:石墨炉法;镉的测定:石墨炉法;铬的测定:石墨炉法;铜的测定:火焰法;砷的测定:氢化物法;汞的测定:冷蒸汽吸收法。结果:铅的进样浓度在0~50 ng·ml^(-1)范围与吸光度线性关系良好,r=0.999 8,平均回收率为98.9%(RSD=2.3%,n=6);镉的进样浓度在0~4 ng·ml^(-1)范围与吸光度线性关系良好,r=0.999 1,平均回收率为90.5%(RSD=1.5%,n=6);铬的进样浓度在0~50 ng·ml^(-1)范围与吸光度线性关系良好,r=0.999 7,平均回收率为96.1%(RSD=1.1%,n=6);铜的进样浓度在0~800 ng·ml^(-1)范围与吸光度线性关系良好,r=0.999 9,平均回收率为97.5%(RSD=1.2%,n=6);砷的进样浓度在0~16 ng·ml^(-1)范围与吸光度线性关系良好,r=0.999 0,平均回收率为93.4%(RSD=1.1%,n=6);汞的进样浓度在0~18 ng·ml^(-1)范围与吸光度线性关系良好,r=0.999 2,平均回收率为93.2%(RSD=3.8%,n=6)。结论:该方法准确,重复性好,可用于铁屑及枸橼酸铁铵的质量控制。
Objective： To establish an atomic absorption spectrophotometric method for the determination of 6 heavy elements including lead,cadmium,mercury,arsenic,copper and chromium in iron filings and ferric ammonium citrate in order to control the quality and ensure people＇s daily medicine safety. Methods： The determination method for lead,cadmium,chromium,copper,arsenic and mercury was a graphite furnace method,a graphite furnace method,a graphite furnace method,a flame method,a hydride method and a cold steam absorption method,respectively. Results： The concentration of lead within the range of 0-50 ng·ml^-1 had a good linear relationship with the absorbance（ r = 0. 999 8）,and the average recovery was 98. 9%（ RSD = 2. 3%,n = 6）. The concentration of cadmium within the range of 0-4 ng·ml^-1 had a good linear relationship with the absorbance（ r = 0. 999 1）,and the average recovery was 90. 5%（ RSD = 1. 5%,n = 6）. The concentration of chromium within the range of 0-50 ng·ml^-1 had a good linear relationship with the absorbance（ r = 0. 999 7）,and the average recovery was 96. 1%（ RSD = 1. 1%,n = 6）. The concentration of copper within the range of 0-800 ng·ml^-1 had a ood linear relationship with the absorbance（ r = 0. 999 9）,and the average recovery was97. 5%（ RSD = 1. 2%,n = 6）. The concentration of arsenic within the range of 0-16 ng·ml^-1 had a good linear relationship with the absorbance（ r = 0. 999 0）,and the average recovery was 93. 4%（ RSD = 1. 1%,n = 6）. The concentration of mercury within the range of 0-18 ng·ml^-1 had a good linear relationship with the absorbance（ r = 0. 999 2）,and the average recovery was 93. 2%（ RSD= 3. 8%,n = 6）. Conclusion： The method with good repeatability is accurate,which can be used for the quality control of iron filings and ferric ammonium citrate.
出处
《中国药师》
CAS
2018年第3期512-515,共4页
China Pharmacist
关键词
铁屑
枸橼酸铁铵
铅
镉
砷
汞
铜
铬
原子吸收分光光度法
Iron filings
Ferric ammonium citrate
Lead
Cadmium
Arsenic
Mercury
Copper
Chromium
Atomic absorption spectrophotometry
