摘要
目的比较替格瑞洛与阿司匹林对脑梗死患者预后的影响。方法选取2016年6月—2017年6月宝鸡高新人民医院神经内科收治的脑梗死患者346例,采用随机数字表法分为阿司匹林组和替格瑞洛组,每组173例。阿司匹林组患者发病后24 h内给予阿司匹林治疗,替格瑞洛组患者发病后24 h内给予替格瑞洛治疗;两组患者均规律服药12个月。比较两组患者治疗前、治疗后1个月、治疗后3个月、治疗后6个月美国国立卫生研究院卒中量表(NIHSS)评分,治疗12个月后脑梗死复发及死亡情况,记录两组患者治疗期间不良反应发生情况。结果治疗前两组患者NIHSS评分比较,差异无统计学意义(P>0.05);治疗后1个月、3个月、6个月替格瑞洛组患者NIHSS评分低于阿司匹林组(P<0.05)。治疗12个月后替格瑞洛组患者复发率低于阿司匹林组(P<0.05),而两组患者病死率比较,差异无统计学意义(P>0.05)。治疗期间两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论与阿司匹林相比,替格瑞洛可更有效地改善脑梗死患者神经功能,降低脑梗死复发率,且安全性较高。
Objective To compare the impact on prognosis in patients with cerebral infarction between ticagrelor and aspirin. Methods From June 2016 to June 2017,a total of 346 patients with cerebral infarction were selected in the Department of Neurology,Baoji Gaoxin Hospital,and they were divided into A group and B group according to random number table,each of 173 cases. Patients in A group received aspirin within 24 hours after attack,while patients in B group received ticagrelor within24 hours after attack; both groups regularly treated for 12 months. NIHSS score before treatment,1 month,3 months and 6 months after treatment,recurrence of cerebral infarction and fatality rate 12 months after treatment were compared between the two groups,and incidence of adverse reactions was observed during the treatment. Results No statistically significant differences of NIHSS score was found between the two groups before treatment（ P〉0.05）,while NIHSS score in B group was statistically significantly lower than that in A group 1 month,3 months and 6 months after treatment,respectively（ P〈0.05）. Recurrence rate of cerebral infarction in B group was statistically significantly lower than that in A group 12 months after treatment（ P〈0.05）,while no statistically significant differences of fatality rate was found between the two groups（ P〉0.05）. No statistically significant differences of incidence of adverse reactions was found during the treatment（ P〈0.05）. Conclusion Compared with aspirin,ticagrelor can more effectively improve the neurological function and reduce the recurrence of cerebral infarction in patients with cerebral infarction,and is relatively safe.
出处
《实用心脑肺血管病杂志》
2017年第12期60-63,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金
国家高技术研究发展计划(863计划)项目(2014AA022304)
关键词
脑梗死
替格瑞洛
阿司匹林
疗效比较研究
Cerebral infarction
Ticagrelor
Aspirin
Comparative effectiveness research
