摘要
目的探讨阿加曲班辅助治疗在伴有早期神经功能恶化的急性缺血性脑卒中患者中的应用效果。方法选取2018年6月至2021年6月张家港市第一人民医院收治的160例急性缺血性脑卒中患者作为研究对象,采用随机摸球法将其分为A组与B组,每组各80例。B组患者采用阿司匹林治疗,A组患者加用阿加曲班辅助治疗。比较两组患者的脑神经功能缺损程度、纤维蛋白原(FIB)、神经肽(NPY)水平。结果两组患者治疗后的改良爱丁堡-斯堪的那维亚神经功能缺损评分量表(MIESSS)评分低于治疗前,且A组患者治疗后的MIESSS评分低于B组,差异有统计学意义(P<0.05)。两组患者治疗后的FIB、NPY水平低于治疗前,且A组患者治疗后的FIB、NPY水平低于B组,差异有统计学意义(P<0.05)。结论伴有早期神经功能恶化的急性缺血性脑卒中患者给予阿加曲班辅助治疗,对脑神经功能缺损程度有显著降低作用,可调节FIB、NPY水平。
Objective To investigate the effect of Agattroban adjuvant therapy in acute ischemic stroke patients with early neurological deterioration.Methods A total of 160 patients with acute ischemic stroke admitted to the First People′s Hospital of Zhangjiagang City from June 2018 to June 2021 were selected as the study subjects.They were divided into group A and group B by random touch ball method,with 80 cases in each group.Patients in group B were treated with Aspirin,and patients in group A were treated with Agattroban.The degree of cerebral nerve function defect,the level of fibrinogen(FIB)and neuropeptide(NPY)in the two groups were compared.Results The modified Edinburgh-Scandinavian neurological impairment score scale(MIESSS)scores of the two groups after treatment were lower than those before treatment,and the MIESSS score of group A was lower than that in the group B,the differences were statistically significant(P<0.05).After treatment,FIB and NPY levels in the two groups were lower than those before treatment,and FIB and NPY levels in group A were lower than those in group B,the differences were statistically significant(P<0.05).Conclusion In acute ischemic stroke patients with early neurological deterioration,adjunctive treatment with Agattroban can significantly reduce the degree of cerebral neurological impairment and regulate the level of FIB and NPY.
作者
徐庶
张雯君
XU Shu;ZHANG Wenjun(Department of Neurology,the First People′s Hospital of Zhangjiagang City,Jiangsu Province,Zhangjiagang215600,China)
出处
《中国当代医药》
CAS
2022年第13期51-53,共3页
China Modern Medicine
基金
江苏省张家港市卫计系统青年科技项目(ZJGQN KJ201805)。
