摘要
目的观察轻型缺血性卒中患者重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓后使用双重抗血小板治疗的临床疗效。方法选取2013年7月~2016年10月在神经内科治疗的80例轻型缺血性卒中患者,按治疗方法分为传统组(n=40)和观察组(n=40)。传统组静脉溶栓后给予阿司匹林长期治疗;观察组静脉溶栓后给予阿司匹林联合氯吡格雷治疗3周,然后继续单用阿司匹林长期治疗。3个月后评估两组患者的NIHSS评分、BI评分、mRS评分,评估3个月内患者的脑出血率、病死率和脑梗死复发率。结果两组患者入院时NIHSS评分差异无统计学意义(P>0.05);治疗3个月后,传统组患者预后情况较观察组差(P<0.05);观察组脑梗死复发率低于传统组,但比较差异无统计学意义(P>0.05)。结论轻型缺血性卒中静脉溶栓后,短期给予双重抗血小板治疗能够提高疗效,脑梗死复发率略有降低,且不增加出血的风险。
Objective To observe the clinical efficacy of dual antiplatelet therapy after the recombinant tissue plasminogen activator(rt-PA)intravenous thrombolysis in patients with light ischemic stroke.Methods80cases of light ischemic stroke patients treated in department of neurology from July,2013to October,2016were selected.All patients were divided into traditional group(n=40)and observation group(n=40)according to treatment method.The traditional group were given long-term aspirin treatment after intravenous thrombolysis;the observation group were treated with aspirin combined with clopidogrel for3weeks after intravenous thrombolysis,and then aspirin alone was continued to be use for long-term treatment.After3months,NIHSS score,BI score and mRS score of the two groups were evaluated,and the cerebral hemorrhage rate,mortality rate and recurrence rate of cerebral infarction were evaluated within3months.Results There was no statistically significant difference in NIHSS scores between the two groups at admission(P>0.05).After3months of treatment,the prognosis of the traditional group was worse than that of the observation group(P<0.05).The recurrence rate of cerebral infarction in the observation group was lower than that in the traditional group,but difference was not statistically significant(P>0.05).Conclusion After the thrombolytic thrombolysis of light ischemic stroke,short-term double antiplatelet therapy can improve the efficacy,reduce the incidence of cerebral infarction,and do not increase the risk of bleeding
作者
张晓鑫
王艳
杨清成
ZHANG Xiaoxin;WANG Yan;YANG Qingcheng(Department of Neurology Two,The Third Affiliated Hospital of Xinxiang Medical College,Xinxiang 453000,China;Anyang People’s Hospital,Anyang 455000,China)
出处
《右江医学》
2017年第6期693-695,共3页
Chinese Youjiang Medical Journal
