摘要
目前,关于维生素B_(12)与男性生育能力的相关作用至今尚未有全面系统的总结。但维生素B_(12)能提高精液质量的有效性得到了充分肯定。它不仅可以增加精子数量,还能提高精子活力和减少精子的DNA损伤;同时也可以增强男性生殖器官的功能,从而提高男性的生育能力。维生素B_(12)能有效提高精液质量的机制在于它可以减弱同型半胱氨酸的毒性,降低DNA甲基化的水平,减轻精子氧化损失的程度,减少炎症诱导的精液质量的损害,控制核因子κB的活化。未来,需要更深入的研究以进一步明确改善男性精液质量所需要的维生素B_(12)的合理剂量,从而为男性不育的临床治疗提供更具体的治疗方法。
At present,the relative function of vitamin B_(12) in the male fertility has not yet been comprehensively and systematically summarized. But the effectiveness of vitamin B_(12) in improving the quality of semen has been fully affirmed. It not only can increase sperm count,but also can improve sperm motility and reduce sperm DNA damage. At the same time,it can also strengthen the function of the male reproductive organs,thereby improving male fertility. The mechanism of vitamin B_(12) effectively improving the quality of semen is that it can reduce the toxicity of homocysteine,reduce the level of DNA methylation and the degree of sperm oxidation damage,reduce inflammation induced damage of semen quality,and control the activation of nuclear factor κB. In the future,further studies are needed to clarify the reasonable dosage of vitamin B_(12) to improve the quality of male semen,thus providing more specific clinical treatment for male infertility.
出处
《医学综述》
2018年第2期362-366,共5页
Medical Recapitulate
