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精子DNA甲基化异常与男性不育 被引量：4

Methylation Abnormality of Sperm DNA and Male Infertility
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摘要 DNA甲基化／去甲基化是表观遗传学最重要的内容并可以控制基因的表达和印迹，越来越多的研究显示DNA甲基化异常与不育男性精子发生异常、特定肿瘤的发生、神经系统疾病、Rett综合征等有关。文章通过总结近来的相关研究资料来阐述精子发生过程中的DNA甲基化状态的改变，探讨精子DNA的甲基化异常与男性不育之间的联系，旨在为男性不育的治疗提供新的临床思路。 DNA methylation is thought to be a crucial content of epigenetics and regulates expression and imprinting of genome. Accumulating data demonstrate that abnormal DNA methylation is involved in spermatogenesis abnormality of male infertility, tumorigenesis, disease of nervous system and Rett syndrome, etc. This review aims to summarize the recent studies on the dynamic changes of sperm DNA methylation in spermatogenesis, discuss the relationship between sperm DNA methylation abnormality and male infertility, and provide a new perspective on treatment for male infertility.
作者 纪梓良 段永刚 蔡志明
机构地区 北京大学深圳医院 深圳市第二人民医院深圳大学第一附属医院 汕头大学医学院
出处 《医学分子生物学杂志》 CAS CSCD 2011年第5期455-460,共6页 Journal of Medical Molecular Biology
基金 国家自然科学基金（No.81070529,30972992）,广东省医学科研基金（No.B2009614）
关键词 精子DNA 甲基化 去甲基化 男性不育 sperm DNA methylation demethylation male infertility
分类号 Q75 [生物学—分子生物学] R697 [医药卫生—泌尿科学]
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参考文献3

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共引文献158

同被引文献59

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医学分子生物学杂志
2011年 第5期

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