摘要
目的探讨女性孕早期血清25（OH）D水平与妊娠相关焦虑之间存在的关联。方法2015年6月至2016年6月间在马鞍山市妇幼保健院进行早孕建档的2122名孕妇为调查对象，通过问卷调查收集相关资料，并于建档时采集孕妇静脉血，采用放射免疫法检测血清25（OH）D水平，使用x。检验、单因素Logistic回归分析和多因素Logistic回归分析等统计学方法对数据进行分析。结果纳人研究的2122名孕早期孕妇，平均年龄（26．95±3．82）岁，平均孕周（9．38±3．01）周。孕早期血清25（OH）D平均值为（29．71±32．27）nmol／L，其中充足者（≥75．00nmol／L）共323名，占15．2％；不足者（50．OO～74．99nmol／L）共480名，占22．6％；缺乏者（25．00～49．99nmol／L）共956名，占45．1％；严重缺乏者（〈25．00nmol／L）共363名，占17．1％。住房类型和25（OH）D检测季节均与孕妇孕早期血清25（0H）D水平之间存在关联。单因素Logistic回归分析，25（OH）D水平缺乏组妊娠相关焦虑发生率高于25（OH）D水平充足组（OR：1．534，95％CI：1．084～2．168），差异具有统计学意义（P〈0．05）；在控制孕妇年龄、体质指数和文化程度等变量后进行多因素Logistic回归分析，25（OH）D水平缺乏组孕妇妊娠相关焦虑发生率高于25（OH）D水平充足组（OR：1．520，95％C1：1．071～2．157）差异具有统计学意义（P〈0．05）。结论孕妇孕早期血清25（OH）D充足率较低，且孕早期血清25（OH）D水平缺乏与孕妇妊娠相关焦虑之间存在负相关性。
Objective To explore the correlation between pregnancy-related anxiety and serum 25 （OH）D level during early pregnancy. Methods A radioimmunoassay was used to determine the serum 25 （OH）D levels of 2 122 early pregnant women in Maanshan Maternal and Child Health Care Hospital, from June 2015 to 2016. Data were collected using a questionnaire. Results The mean serum 25（OH）D level was （29.71±32.27） nmol/L. About 15.2% of the subjects had adequate, 22.6% had insufficient, 45.1% had deficient, and 17.1% had severely deficient serum 25（OH）D levels. The type of housing and testing seasons were significantly associated with the serum 25（OH）D level. Single factor logistic regression analysis results show that pregnancy-related anxiety incidence in the group deficient in 25（OH）D was higher than that in the adequate group, which has a statistically significant difference （P〈0.05）. After adjusting for the maternal age, BMI, and educational level, multivariate logistic regression analysis results showed that the difference was statistically significant. Conclusion The serum 25（OH）D level in early pregnant women was inadequate. Furthermore, lack of serum 25（OH）D in early pregnancy and pregnancy-related anxiety were negatively correlated.
出处
《中华健康管理学杂志》
CAS
2017年第6期548-552,共5页
Chinese Journal of Health Management
基金
国家自然科学基金（81330068）
中国疾病预防控制中心妇幼保健中心“2015年度合生元母婴营养与健康研究项目”（2015FYH006）
2015年度马鞍山市科技计划项目
马鞍山市卫生局第十批局科教专项资金资助课题
关键词
妊娠
维生素D
焦虑
Pregnancy
Vitamin D
Anxiety
