摘要
目的探讨异丙托溴铵联合无创呼吸机治疗对慢性阻塞性肺疾病(COPD)合并呼吸衰竭患者的临床疗效,为COPD合并呼吸衰竭患者临床治疗提供新的思路。方法选取2015年2月至2016年12月我院收治的COPD合并呼吸衰竭患者90例,随机分为对照组和研究组,每组各45例,两组患者均实施抗炎、平喘、化痰、吸氧等常规治疗,对照组患者实施无创呼吸机治疗,研究组患者在对照组基础上给予异丙托溴铵雾化治疗(异丙托溴铵500μg+生理盐水1 ml雾化吸入,3次/d),两组患者均治疗7 d,比较两组患者治疗前后血气分析、肺功能、CAT评分、Borg评分变化。结果与治疗前比较,两组患者治疗后PaO_2、FEV1、FEV1/FVC明显升高,PaCO_2明显降低,差异具有统计学意义(P<0.05)。与对照组治疗后比较,研究组治疗后PaO_2、FEV_1、FEV_1/FVC显著升高,PaCO_2显著降低,差异具有统计学意义(P<0.05)。与治疗前比较,两组患者治疗后CAT评分、Borg评分明显降低,差异具有统计学意义(P<0.05)。与对照组治疗后比较,研究组治疗后CAT评分、Borg评分显著降低,差异具有统计学意义(P<0.05)。结论异丙托溴铵联合无创呼吸机在治疗COPD合并呼吸衰竭中发挥协同作用,可有效缓解气流受阻症状,改善患者的肺功能,提高患者的临床疗效和生活质量,值得推广应用。
Objective To investigate the clinical effect of ipratropium bromide combined with noninvasive ventilation therapy in patients with chronic obstructive pulmonary disease( COPD) and respiratory failure,in order to provide a new idea for the clinical treatment of COPD patients with respiratory failure.Methods All 90 patients of COPD with respiratory failure were randomly divided into control group and research group from February 2015 to December 2016 in Department of Respiratory,Jiangsu Jiangyin People's Hospital. Each group had 45 cases. The two groups of patients were treated with anti-inflammation,antiasthma,reducing phlegm,oxygen therapy and other conventional treatment methods. The control group was treated with non-invasive ventilation therapy,and the research group was treated with ipratropium bromide on the basis of the control group( aerosol inhalation with ipratropium bromide 500 μg and NS 1 ml tid). After 7 days' treatment,the blood gas analysis,lung function,CAT score,Borg score of two groups before and after treatment were compared. Results The Pa O2,FEV1,FEV1/FVC of two groups after treatment increased significantly,and the Pa CO2 decreased significantly,the difference was statistically significant( P < 0. 05).Comparing with control group after treatment,the Pa O2,FEV1,FEV1/FVC of research group after treatment increased obviously,and the Pa CO2 decreased obviously,the difference was statistically significant( P<0.05).CAT score,Borg score of two groups after treatment decreased significantly,the difference was statistically significant( P<0.05). Comparing with control group after treatment,CAT score,Borg score of research group after treatment decreased obviously,the difference was statistically significant( P < 0. 05). Conclusions Isopropyl bromide combined with noninvasive ventilator plays a synergistic role in the treatment of COPD combined respiratory failure. It can effectively alleviate the symptoms of airflow obstruction,improve the lung function,the clinical effect and quality of life of pati
出处
《中华肺部疾病杂志（电子版）》
CAS
2017年第6期673-676,共4页
Chinese Journal of Lung Diseases(Electronic Edition)
基金
解放军总后勤部"十一五"青年杰出人才基金资助(06MA036)
关键词
肺疾病
慢性阻塞性
呼吸衰竭
异丙托溴铵
无创呼吸机
Chronic obstructive pulmonary disease
Respiratory failure
Ipratropium bromide
Non-invasive breathing machine
