摘要
目的探讨阿立哌唑治疗儿童青少年精神分裂症的血清药物浓度与临床疗效的关联性。方法纳入27例应用阿立哌唑治疗的儿童青少年精神分裂症患者,观察8周,采用高效液相色谱法(HPLC)测定阿立哌唑的血清药物浓度,以阳性和阴性症状量表(PANSS)评定药物治疗效果,以治疗时出现的症状量表(TESS)评定药物不良反应,使用SPSS 18.0统计软件对血药浓度与临床疗效评分进行统计分析。结果治疗第1周末阿立哌唑血药浓度与PANSS减分率无相关性(r=0.201,P>0.05),第2周末血药浓度与PANSS减分率有相关趋势(r=0.352,P=0.055),而第4、8周末血药浓度与PANSS减分率呈显著正相关(r>0.503,P<0.05)。有效组患者的血药浓度高于无效组,最低有效浓度为285.2 ng/ml,发生不良反应的药物浓度阈值为440 ng/ml。结论阿立哌唑治疗儿童青少年精神分裂症较适宜的血药浓度范围为285.2~440ng/ml,血药浓度与临床疗效之间存在着相关性。
Objective To investigate the correlation between serum concentration of aripiprazole and its clinical efficacy in the treatment of children and adolescent patients with schizophrenia.Methods 27 cases of children and adolescent patients with schizophrenia received oral non-fixed dosage of aripiprazole for 8 weeks.The serum concentration of aripiprazole was determined with High Performance Liquid Chromatography（HPLC）.The psychotic symptoms of patients were evaluated with Positive and Negative Syndrome Scale（PANSS）and the adverse reactions were assessed with Treatment Emergent Symptom Scale（TESS）.Results There was no correlation between the serum concentration of aripiprazole and the reduction rate of PANSS scores at the end of first week（r=0.201,P〉0.05）.A trend towards to positive correlation between the serum concentration of aripiprazole and the reduction rate of PANSS scores was found at the end of second week（r=0.352,P=0.055）,and significant correlations were observed at the end of both fourth and eighth weeks（r〉0.503,P〈0.05）.No relationship was found between the oral dosage of aripiprazole and the clinical efficacy.The mean concentration of aripiprazole in effective group was higher than that of ineffective group.The lowest effective concentration of aripiprazole was 285.2 ng/ml and the concentration threshold occurring side effects was 440 ng/ml.Conclusion The serum concentration of aripiprazole is correlated with its clinical efficacy in the treatment of children and adolescent patients with schizophrenia,and the suitable concentration range is 285.2~440 ng/ml.
出处
《国际精神病学杂志》
2017年第6期987-990,共4页
Journal Of International Psychiatry
基金
南昌市科技支撑计划项目(编号:2014SFZC017)
江西省科技计划项目(编号:20151BBG70110)
关键词
阿立哌唑
儿童青少年
精神分裂症
血药浓度
临床疗效
Schizophrenia
Children and adolescent patients
Aripiprazole
Serum concentration
Clinical efficacy
