摘要
目的探讨阿立哌唑联合无抽搐电休克(MECT)治疗女性难治性精神分裂症临床疗效及不良反应。方法将新乡医学院第二附属医院2014年7月至2016年5月收治的女性难治性精神分裂症患者105例分为对照组和观察组,对照组52例给予阿立哌唑口服治疗,观察组53例给予阿立哌唑联合MECT治疗。2组患者均治疗8周。采用阳性与阴性症状量表(PANSS)评定临床疗效;采用韦氏记忆量表(WMS)评定MECT对记忆的影响;采用药物不良反应量表(TESS)评定2组患者治疗后不良反应发生情况。结果最终纳入分析的患者103例,观察组脱落2例,对照组无脱落。治疗前2组患者PANSS评分比较差异无统计学意义(P>0.05);2组患者治疗第2周末的阳性症状评分、一般精神病理及PANSS总分均较治疗前显著降低(P<0.05);在治疗4、8周末,2组患者阴性症状评分、阳性症状评分、一般精神病理评分及PANSS总分均较治疗前显著降低(P<0.05,P<0.01)。治疗4周末,观察组患者阳性症状评分、一般精神病理评分、PANSS总分显著低于对照组(P<0.05);治疗8周末,观察组患者阴性症状评分、阳性症状评分、一般精神病理评分及PANSS总分显著低于对照组(P<0.05)。治疗8周末,观察组和对照组患者PANSS减分率分别为(39.89±8.62)%和(31.97±8.17)%,观察组和对照组患者治疗总有效率分别为66.67%和48.08%,观察组患者PANSS减分率和治疗总有效率均显著高于对照组(P<0.05)。治疗2周末,观察组患者WMS评分较治疗前显著降低(P<0.05);治疗4周末,WMS中图片因子评分低于治疗前(P<0.05);治疗8周末,WMS各因子评分与治疗前比较差异无统计学意义(P>0.05)。2组患者治疗后TESS评分及不良反应发生率比较差异均无统计学意义(P>0.05)。结论与单一应用阿立哌唑相比,MECT联合阿立哌唑可显著提高女性难治性精神分裂症患者的治疗效果,且不增加不良反应。
Objective To investigate the efficacy and side effects of aripiprazole combined with modified electroconvulsive therapy （MECT） in the treatment of female refractory schizophrenia.Methods One hundred and five female refractory schizophrenia patients in the Second Affiliated Hospital of Xinxiang Medical University from July 2014 to May 2016 were selected and divided into control group and observation group.Fifty-two patients in the control group were treated with aripiprazole.In the observation group,53 patients were treated with aripiprazole combined with MECT.All the patients were treated for eight weeks.Clinical efficacies were assessed with the positive and negative syndrome syndrome scale （PANSS）;Wechsler memory scale （WMS） were used to evaluate the effect of MECT on memory.Adverse drug reactions were evaluated by treatment emergent symptom scale（TESS） before and after treatment in both groups.Results There was no significant difference in PANSS scores between the two groups before treatment （P 〉 0.05）.The positive symptom scores,the general mental pathology scores and the PANSS total scores in the two groups at the end of the second week were significantly lower than before treatment（P 〈 0.05）;at the end of fourth and eighth week of treatment,the negative symptom scores,the positive symptom scores,the general psychopathological scores and the PANSS total scores of the two groups were significantly lower than those before treatment （P 〈 0.05 or P 〈 0.01）.The positive symptoms,the general psychopathological scores and the PANSS total score in the observation group were significantly lower than those in the control group at the end of fourth week of treatment （P 〈0.05）.At the end of the eighth week of treatment,the negative symptom scores,the positive symptom scores,the general psychopathological scores and the PANSS total scores in the observation group were significant lower than those in the control group （P 〈 0.05）.At the end of the eighth week of treatment,the
出处
《新乡医学院学报》
CAS
2017年第9期847-850,共4页
Journal of Xinxiang Medical University
关键词
阿立哌唑
无抽搐电休克
女性
难治性精神分裂症
aripiprazole
modified electroconvulsive therapy
female
refractory schizophrenia
