摘要
目的：了解医院2014-2015年尿病原菌分布和耐药性.方法：对2014-2015年我院所有尿培养检出的病原菌进行统计分析.结果：共检出病原菌536株,革兰阴性（G-）菌398株,占74.3%,革兰阳性（G＋）菌110株,占20.5%,真菌28株,占5.2%.检出率前5位的是大肠埃希菌（38.8%,208/536）、 屎肠球菌（8.4%,45/536）、 肺炎克雷伯菌（8.2%,44/536）、凝固酶阴性葡萄球菌（6.1%,33/536）和铜绿假单胞菌（6.0%,32/536）.碳青酶烯类抗菌药对大肠埃希菌和肺炎克雷伯菌抗菌活性最强,对铜绿假单胞菌抗菌活性较差;革兰阳性球菌对糖肽类和利奈唑胺抗菌药物高度敏感.结论：尿培养分离的病原菌菌种复杂、 耐药情况严重,临床应积极开展病原菌分布及其耐药性监测,及时调整抗菌药物.
Objective： This study aims to investigate the distribution and antibiotic resistance of common bacteria isolated from urine culture samples collected from 2014 to 2015. Methods： Distribution and antibiotic resistance of pathogens in 536 urine culture-positive patients from 2014 to2015 were analyzed. Results： Pathogenic strains isolated from 536 patients were collected from the urine specimens in this survey, which includs 398 （74.3%） strains of Gram-negative bacilli, 110 （20.5%） strains of Gram-positive cocci and 28 （5.2%） strains of fungi. The top five pathogens were Escherichia coli （38.8%, 208/536） , Enterococcn faecium （8.4%, 45/536） , Klebsiella pneumoniae （8.2~/O, 44/536 ） , coagulase negative staphylococci （6.1%, 33/536） , and Pseudomonas aemginosa （6.0%, 32/536） . Carbopenems showed the most anfimicrobial activity to E. coli and K. p neumoniae, but the susceptibility ofP. aeruginosa to carbopenems reduced. Gram-positive cocci were highly sensitive to glycopeptides and linezolick Conclusion： Bacterial species isolated from urine cultures diversified and the antibiotic resistance is serious. Distribution of the pathogenic bacteria and their drug resistance should be monitored continuously, which could modify treatment timely.
出处
《医学检验与临床》
2017年第9期25-29,共5页
Medical Laboratory Science and Clinics
关键词
尿培养
病原菌
耐药性
抗菌药物
Urine culture
Pathogenic bacteria
Drug resistance
Antibiotics
