摘要
目的了解2013年上海市青浦地区革兰阳性菌细菌耐药性监测结果,为临床合理使用抗菌药物提供依据。方法采用自动化仪器对青浦地区2所医院临床分离的革兰阳性菌进行药敏试验,采用CLSI 2014年版标准判断结果。结果 315株革兰阳性菌中,肠球菌属细菌、金黄色葡萄球菌(金葡萄)和凝固酶阴性葡萄球菌分别占40.3%(127/315)、36.5%(115/315)、20.3%(64/315)。耐甲氧西林金葡菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)的检出率分别为48.7%和82.8%。甲氧西林耐药株对临床常用抗菌药物的耐药率均高于甲氧西林敏感株。葡萄球菌属和链球菌属细菌中未发现万古霉素和利奈唑胺耐药株。发现1株万古霉素耐药屎肠球菌和2株粪肠球菌。结论细菌耐药性仍对临床构成严重威胁,应引起临床严重关注。
Objective To investigate the antibiotic resistance of clinical gram-positive bacteria isolated from hospitals in Qingpu District from January through December of 2013. Methods Antimicrobial susceptibility testing was carried out for the clinical gram-positive isolates according to an agreed protocol using automated system. Results were analyzed according to the CLSI breakpoints released in 2014. Results Of the 315 isolates, Enterococcus spp. , Staphylococcus aureus, and coagulase-negative Staphylococcus accounted for 40. 3% （127/315）, 36. 5% （115/315）, and 20. 3% （64/315）, respectively. The overall prevalence of methicillin resistant strains was 48. 7% in S. aureus （MRSA）, and 82. 8% in coagulase-negative Staphylococcus. MRSA strains were more resistant to antimicrobial agents than methicillin-sensitive strains. No Staphylococcus or Streptococcus strains were found resistant to vancomycin or linezolid. Overall, one strain of E. faeciurn and 2 strains of E. faecalis were found resistant to vancomycin. Conclusions Antibiotic resistance poses a serious threat to clinical practice, to which more attention should be paid.
出处
《中国感染与化疗杂志》
CAS
CSCD
北大核心
2015年第4期368-371,共4页
Chinese Journal of Infection and Chemotherapy
基金
上海市青浦区科学技术委员会青发科2013-18
关键词
细菌耐药性监测
药物敏感性试验
万古霉素耐药肠球菌
甲氧西林耐药葡萄球菌
bacterial resistance surveillance
antimicrobial susceptibility testing
vancomycin-resistant Enterococcus
methicillin resistant Staphylococcus
