摘要
目的了解2013年上海市青浦地区临床分离的革兰阴性菌对抗菌药物的敏感性。方法采用自动化仪器对该地区2所医院临床分离的革兰阴性菌进行药敏试验,采用CLSI 2013年版标准判断结果。结果总计1 376株革兰阴性菌中,大肠埃希菌、克雷伯菌属和奇异变形杆菌中产超广谱β内酰胺酶(ESBL)菌株的检出率分别为66.7%、28.7%和12.5%。产ESBL菌株对临床常用抗菌药物的耐药率均高于非产ESBL菌株。肠杆菌科细菌对碳青霉烯类抗生素仍高度敏感,对亚胺培南和阿米卡星的总耐药率分别为4.2%和6.8%。铜绿假单胞菌和不动杆菌属对亚胺培南的耐药率分别为17.1%、36.0%。大肠埃希菌、肺炎克雷伯菌、鲍曼不动杆菌和铜绿假单胞菌中有少数菌株对所有测试的药物耐药。结论细菌耐药性仍对临床构成严重威胁,应引起临床关注。
Objective To investigate the antibiotic resistance in clinical strains of gram‐negative bacteria isolated from the hospitals in Qingpu District from January through December during 2013 .Methods Antimicobial susceptibility testing was carried out for the gram‐negative isolates according to an agreed protocol using automated system .Results were interpreted according to CLSI 2013 breakpoints .Results A total of 1 376 clinical isolates were included in this analysis . The overall prevalence of ESBLs‐producing srains was 66 .7% in E .coli ,28 .7% in K lebsiella spp .and 12 .5% in P .mirabilis .ESBL‐positive strains were more resistant to antimicrobial agents than ESBL‐negative strains . Enterobacteriaceae strains were still highly susceptible to carbapenem antibiotics .Overall ,4 .2% and 6 .8% of the Enterobacteriaceae strains were resistant to imipenem and amikacin ,respectively .About 17 .1% of the P .aeruginosa strains and 36 .0% of the Acinetobacter spp .strains were resistant to imipenem .A few extensively drug‐resistant strains were identified in E .coli ,K .pneumoniae ,A .baumannii and P . aeruginosa .Conclusions Antibicotic resistance is a serious threat to clinical practice .Management and control of extensively drug‐resistant bacteria is a great concern of clinicians .
出处
《中国感染与化疗杂志》
CAS
CSCD
北大核心
2015年第3期264-268,共5页
Chinese Journal of Infection and Chemotherapy
基金
上海市青浦区科学技术委员会青发科2013-18
关键词
细菌耐药性监测
药物敏感性试验
广泛耐药菌
超广谱b内酰胺酶
bacterial resistance surveillance
antimicrobial susceptibility testing
extensively drug-resistant bacteria
extended-spectrum beta-lactamase
