摘要
目的:探讨阿司匹林联合阿托伐他汀对缺血性脑血管病(ICVD)患者血清炎性因子和颈动脉斑块的影响。方法:选取我院自2015年1月至2016年1月收治的ICVD患者86例为病例组,按随机数字表法分为对照组和研究组各43例,对照组给予常规治疗同时口服阿司匹林,研究组在对照组的基础上联合阿托伐他汀治疗,两组均治疗12个月。另选同期在我院体检的健康者86例为健康组。检测并对比所有研究对象血清中氧化修饰低密度脂蛋白(OX-LDL)和超敏C-反应蛋白(hs-CRP)水平;对比治疗前、治疗后1 d研究组与对照组颈动脉内中膜厚度(IMT)、颈动脉斑块面积、神经功能缺损评分(NIHSS)以及日常生活能力评分(BI)。结果:病例组治疗前血清中hs-CRP、OX-LDL水平均显著高于健康组,差异有统计学意义(P<0.05);治疗后1d研究组和对照组血清中OX-LDL、hs-CRP、IMT、颈动脉斑块面积和NIHSS评分低于治疗前,BI评分高于治疗前,且研究组血清中OX-LDL、hs-CRP、IMT、颈动脉斑块面积和NIHSS评分低于对照组,BI评分高于对照组,差异均有统计学意义(P<0.05)。研究组和对照组不良反应发生率比较差异无统计学意义(P>0.05)。结论:阿司匹林联合阿托伐他汀治疗ICVD患者,能有效降低血清中炎性因子OX-LDL、hs-CRP水平,减小IMT和颈动脉斑块面积,有助于患者更好更快的恢复,较单用阿司匹林治疗效果更为明显,值得临床推广。
Objective： To investigate the effect of aspirin combined with atorvastatin on serum inflammatory factors and carotid plaque in patients with ischemic cerebrovascular disease （ICVD）. Methods： A total of 86 patients with ICVD, who were treated in Wanbei Coal-Electricity Group General Hospital from January 2015 to January 2016, were chosen as case group and randomly divided into control group （n=43） and research group （n=43）. The control group was received conventional treatment and oral aspirin, the research group was treated with atorvastatin on the basis of the control group＇s therapy. The two groups were treated for 12 months. Another 86 healthy people, who were examined in this hospital, were chosen as healthy group at the same time. Serum oxidized low density lipoprotein （OX-LDL） and hypersensitive C- reactive protein （hs-CRP） levels were detected and compared in all the subjects. The carotid intima-media thickness （IMT）,the carotid plaque area,the neurological impairment score （NIHSS） and the daily living ability score （BI） were compared between the research group and the control group before and ld after treatment. Results： The serum levels of hs-CRP and OX-LDL in the research group and the control group before treatment were significantly higher than those in the healthy group, and the difference was statistically significant （P〈0.05）. 1 d after treatment,the serum OX-LDL, hs-CRP, IMT, carotid plaque area and NIHSS score in the research group and the control group were lower than before treatment and the BI scores were higher than before treatment, and the serum OX-LDL, hs-CRP, IMT,carotid plaque area and NIHSS score in the research group were lower than those in the control group and the BI score was higher than that in the control group, the difference was statistically significant （P〈0.05）. There was no significant difference in the adverse reaction rate between the research group and the control group （P〉0.05）. Conclusion： Compared with aspirin
出处
《现代生物医学进展》
CAS
2017年第35期6913-6916,6941,共5页
Progress in Modern Biomedicine
