摘要
目的观察颜氏降脂方治疗脾虚痰瘀型血脂异常的临床疗效及对患者颈动脉斑块的影响。方法将120例脾虚痰瘀型血脂异常患者按照随机数字表法分为2组。治疗组60例予颜氏降脂方治疗,对照组60例予血脂康胶囊治疗。2组均治疗12周后统计临床疗效,并比较2组治疗前后胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,中医证候改善情况,颈动脉内膜-中层厚度(IMT)、颈动脉斑块面积,以及不良反应情况。结果治疗组总有效率88.33%(53/60),对照组总有效率85.00%(51/60),2组比较差异无统计学意义(P>0.05),临床疗效相当。治疗后2组TC、TG、LDL-C均较本组治疗前降低(P<0.05),HDL-C均升高(P<0.05),且治疗组TG低于对照组(P<0.05);治疗后2组组间TC、LDL-C、HDL-C比较差异均无统计学意义(P>0.05)。治疗后治疗组眩晕、倦怠乏力、肢体沉重、头重如裹、形体肥胖、胸闷、口淡均较本组治疗前改善(P<0.05),治疗后对照组眩晕、倦怠乏力、肢体沉重、头重如裹、胸闷、口淡均较本组治疗前改善(P<0.05),且治疗组眩晕、倦怠乏力、肢体沉重、头重如裹、胸闷、口淡改善优于对照组(P<0.05)。2组治疗前后颈动脉IMT、颈动脉斑块面积组间、组内比较差异均无统计学意义(P>0.05)。对照组不良反应发生率16.7%(10/60),治疗组均未出现不良反应,治疗组不良反应发生率低于对照组(P<0.05)。结论颜氏降脂方治疗脾虚痰瘀型血脂异常疗效确切,且不良反应少,安全性高。
Objective To observe the effect of Yan's Jiangzhi recipe on dyslipidemia of spleen deficiency and phlegm stasis type and its effect on carotid plaque.Methods 120 patients with dyslipidemia of spleen deficiency and phlegm stasis type were divided into two groups according to the random number table method.60 cases in the treatment group were treated by Yan's Jiang Zhi recipe.60 cases in the control group were treated by Xuezhikang capsule.After 12 weeks of treatment,the clinical effects of the two groups were statistically analyzed,and the levels of cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),TCM syndrome score,carotid intima-media thickness(IMT),carotid plaque area and adverse reactions before and after treatment were compared.Results The total effective rate was 88.33%(53/60)in the treatment group and 85.00%(51/60)in the control group.There was no significant difference between the two groups(P>0.05),the clinical effect is equivalent.After treatment,TC,TG and LDL-C in the two groups were lower than those in the group before treatment(P<0.05),HDL-C was increased(P<0.05),and TG in the treatment group was lower than that in the control group(P<0.05).There was no significant difference in TC,LDL-C and HDL-C between the two groups(P>0.05).After treatment,vertigo,limb tiredness,heavy limbs,heavy head,fat body,chest distress and light mouth in the treatment group were improved compared with those before treatment(P<0.05).After treatment,vertigo,limb tiredness,heavy limbs,heavy head,chest distress and light mouth in the control group were improved compared with those before treatment(P<0.05).The treatment group was better than the control group in improving vertigo,limb tiredness,heavy limbs,heavy head,chest distress and light mouth(P<0.05).There was no significant difference in IMT and plaque area between the two groups(P>0.05).The incidence of adverse reactions was 16.7%(10/60)in the control group.There was no adverse reaction in the treatment
作者
刘珺
王博
颜琼枝
孔令越
郭乐杭
王莉
范俊飞
韩天雄
夏韵
颜乾麟
LIU Jun;WANG Bo;YAN Qiongzhi(Department of Traditional Chinese Medicine,The 10th People's Hospital Affiliated to Tongji University,Shanghai 200072)
出处
《河北中医》
2020年第3期341-345,350,共6页
Hebei Journal of Traditional Chinese Medicine
基金
上海市卫生和计划生育委员会中医药科研基金课题(编号:2014LQ108A)
上海市科委中医引导项目(编号:15401934700)
上海市进一步加快中医药事业发展三年行动计划项目〔编号:ZY(2018-2020)-CCCX-1003〕。
关键词
血脂异常
中药疗法
斑块
动脉粥样硬化
Dyslipidemia
Traditional Chinese medicine therapy
Plaque
atherosclerosis
