摘要
目的:分析同型半胱氨酸(Hcy)、过氧化氢酶(CAT)、维生素B6在精神分裂症患者中的表达及临床。方法:67例精神分裂症患者来自于我院2015年12月~1016年12月,均予以阿立哌唑治疗。同期选择我院门诊健康体检者67例作为对照组。比较精神分裂症组与对照组Hcy、CAT及B6水平,并分析精神分裂症患者Hcy、CAT、B6水平与阳性或阴性症状量表(PANSS)评分的相关性。结果:精神分裂症组Hcy水平显著高于对照组,CAT、B6水平明显低于对照组,差异有统计学意义(P<0.05)。精神分裂症患者Hcy、CAT、B6水平阳性检测率分别为86.57%、79.10%、71.64%。Hcy水平与PANSS总分呈正相关,CAT、B6水平与PANSS总分呈负相关(r分别为0.856、-0.764、-0.803,P<0.05)。结论:精神分裂症患者Hcy呈高表达,CAT及B6水平相对较低,因此联合测定其水平能够诊断病情进展及判断预后。
Objective： To analyze the expressions and significance of homocysteine （Hcy）, catalase （CAT） and vitamin B6 in patients with schizophrenia. Methods： 67 patients with schizophrenia who were treated in our hospital from December 2015 to December 2016 Were selected as the research objects, and another 67 health people who had taken the examination in our outpatient clinic were chosen to be the healthy control group. Then the levels of Hcy, CAT and B6 in patients with schizophrenia and the control group were detected, and the correlation of Hey, CAT and B6 expressions and the positive or negative symptom scale（PANSS） scores were analyzed. Results： The level of Hcy in the schizophrenia group was significantly higher than that of the control group, while the levels of CAT and B6 in the schizophrenia group were signifieantly lower than those of the control group, and the differences were statistically significant （P〈0.05）. The positive rate of Hcy, CAT and B6 in schizophrenia group was 86.57 %, 79.10% and 71.64%, respectively. The level of Hcy was positively correlated with the PANSS score, while the levels of CAT and B6 was negatively correlated with the PANSS score （r=0.856, -0.764, -0.803, P〈0.05）. Conclusion： The level of Hcy in patients with schizophrenia was higher, while the levels of CAT and B6 were lower. Therefore, the determination of the levels of Hcy, CAT and B6 in schizophrenia patients could help to diagnosis the dis- ease and evaluate the prognosis.
出处
《现代生物医学进展》
CAS
2017年第35期6878-6881,共4页
Progress in Modern Biomedicine
基金
四川省卫生厅科研基金项目(090064)
