摘要
目的观察托烷司琼联合咪达唑仑降低卡前列素氨丁三醇引发剖宫产产妇不良反应的效果。方法选取剖宫产术中宫缩乏力使用卡前列素氨丁三醇的产妇80例,随机分为A组和B组,每组40例。A组静脉注射托烷司琼5 mg,B组静脉注射托烷司琼5 mg后再静脉注射咪达唑仑2 mg。观察并记录产妇入室(T0)、用卡前列素氨丁三醇前(T1)、用药后10 min(T2)、用药后20 min(T3)、术毕(T4)等时间点的BP、HR、SpO_2的变化及不良反应的发生情况。结果 B组在T2、T3时间点SBP、DBP、HR低于A组(P<0.05)。B组心悸、胸闷、面部潮红、血压升高不良反应发生率低于A组(P<0.05或P<0.01)。结论托烷司琼联合咪达唑仑可降低卡前列素氨丁三醇引发的剖宫产产妇的不良反应。
Objective To observe the clinical effect of tropisetron combined with midazolam reduced the adverse re- action in patients undergoing caesarean section induced by the romethamine injection. Methods select 80 cases of uterine at- ony during cesarean section used romethamine injection in accordance with the random digital table method were divided into group A （ observation group, n = 40） with intravenous injection of tropisetron 5 mg and group B （ control group, n = 40） with in- travenous injection of tropisetron 5 mg and intravenous injection of midazolam 2 mg. The changes of Bp, HR, SpO2 patients in two groups at the time points of patients ariving operating room （ TO ）, befre using romethamine injection （ T1 ）, after using 10 min （ T2 ）, after using 20 min （ T3 ）, at the end of operation （ T4 ） and the numbers occur of adverse reactions were observed and recorded. Results The patients＇ HR, Bp at the time points of T2, T3 in group A were higher than those of group B, and the difference was statistically significant （P 〈 0.05 ）. The palpitations, chest tightness, facial flushing and the adverse reaction of elevated blood pressure rate of group B was lower than that of A group （ P 〈0. 05 or P 〈 0.01 ）. Conclusion Tropisetron combined with midazolam can significantly reduce the adverse reactions of cesarean section induced by the romethamine injection.
出处
《临床合理用药杂志》
2017年第35期21-22,12,共3页
Chinese Journal of Clinical Rational Drug Use
