摘要
目的探讨卡前列甲酯栓预防产妇产后出血的效果及安全性。方法将我院收治的294例住院产妇随机分为观察组和对照组。观察组159例,给予卡前列甲酯栓;对照组135例,静脉注射缩宫素。比较两组产妇第三产程时间、产后2 h出血量、血压变化和不良反应发生情况。结果观察组产后2 h出血量及第三产程时间均显著低于对照组,两组比较差异有统计学意义(P<0.05);两组产妇用药前后血压变化比较差异无统计学意义(P>0.05)。产妇用药后主要不良反应有腹泻、恶心、发热,两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论采用卡前列甲酯栓预防产后出血,可明显降低产后出血量和第三产程时间,且不增加不良反应发生率,使用安全有效,值得临床推广应用。
Objective To discuss the preventive effect and safety of carboprost methylate suppositorites in the treatment of postpartum hemorrhage. Methods 294 patients in our hospital were randomly divided into observation group and control group. Observation group （ n = 159 ） was treated with carboprost methylate suppositorites, control group（n = 135）was given intravenous injection of oxytocin. The amount of postpartum 2 h bleeding,the time of the third stage of labor, change of blood pressure and adverse reactions were compared between the two groups. Results There were significant differences in the amount of postpartum 2 h bleeding and the time of the third stage of labor between the two groups （P 〈 0. 05 ） ;no significant difference was found in the change of blood pressure before and after the medication（ P 〉 0. 05 ）, The main adverse reactions were manifested as diarrhea ,nausea, fever,there was no significant difference in the total inodence of adverse reactions between the two groups （ P 〉 0. 05 ）. Conclusion Carboprost methylate suppositorites has preventive effect on the postpartum hemorrhage ,it can reduce the amount of postpartum 2 h bleeding and the time of the third stage of labor, and did not increase the incidence of adverse reaction, it is worthy of clinical application.
出处
《实用药物与临床》
CAS
2014年第2期240-242,共3页
Practical Pharmacy and Clinical Remedies
关键词
卡前列甲酯栓
缩宫素
产后出血
预防效果
安全性
Carboprost methylate suppositorites
Oxytocin
Postpartum hemorrhage
Prevention effect
Safety
