摘要
目的探讨缺血修饰白蛋白、同型半胱氨酸在老年急性冠状动脉综合征早期诊疗中的影响。方法遵循统计学办法,按照随机数字表,随机选取就诊于我院的120例急性冠脉综合症患者(自发病起至入院就诊时间<24h,后经冠脉造影确诊)为观察组,同时选取40例来我院体检人员设为对照组。观察两组患者在不同时间缺血修饰白蛋白(IMA)、同型半胱氨酸(Hcy)变化,同时监测冠状动脉支数病变、Gensini积分与其相对变化关系。结果 IMA水平在初始1~6h观察组与对照组比较差异有统计学意义(P<0.05)。在12~24h时,观察组与对照组比较差异有统计学意义(P<0.05),但12~24h时IMA≤85.0U/mL,其为阴性结果,不可做相应参考。冠状动脉狭窄程度积分与同型半胱氨酸比较结果可见,16~32分组的Hcy水平高于0~15分组,差异有统计学意义(P<0.05)。>32分组的Hcy水平高于其他两组差异有统计学意义(P<0.05)。提示冠状动脉狭窄程度积分程度的增加,Hcy水平也随之增加。冠状动脉支数与同型半胱氨酸比较可见,双支病变组的Hcy水平高于单支病变组,差异有统计学意义(P<0.05)。三支病变组的Hcy水平高于其他两组,差异有统计学意义(P<0.05)。提示病变支数严重程度的增加,Hcy水平也随之增加。结论缺血修饰白蛋白、同型半胱氨酸在老年急性冠状动脉综合征早期诊疗中有一定临床意义。
Objective To explore the effects of ischemic modified albumin and homocysteine on early diagnosis and treatment for elderly patients with acute coronary syndromes.Methods According to the random number table,randomly selected 120 cases of patients with syndrome of acute coronary artery （from onset to hospital admission,less than 24hours after coronary angiography） in author＇s hospital as the experimental group, and selected 40 cases in the same hospital physical examination personnel set for the control group.The changes of ischemia modified albumin and homocysteine in the two groups were observed at different times,and the rela- tive changes of coronary artery count, Oensini score and coronary artery count were observed. Results The study showed that the level of IMA was significantly different between the experimental group and the control group at the initial 1- 6hours （P〈0.05）.In 12- 24h,the experimental group and control group with significant difference （P〈0.05）,but the 12- 24h IMA was less than or equal to 85.0U/mL,the negative results, not to do the corresponding reference.Comparing the degree of coronary stenosis with homocysteine,we could see that the level of Hcy in the 16- 32 groups was higher than that in the 0- 15 groups,P〈0.05.The level of Hcy in the 32 groups was significantly higher than that in the other two groups,P〈0.05.It suggested that the degree of coronary artery stenosis was increased,and the level of Hcy was increased.On coronary artery count and homoeysteine,the Hcy level in the double branch disease group was higher than the single vessel pathological change group,P〈0.05.The level of Hcy in the three lesions group was significantly higher than that in the other two groups,P〈0.05.It indicated that the number of lesions increased and the level of Hcy increased.Conclusion Ischemia modified albumin and homocysteine have some clinical significance in the early diagnosis and treatment of elderly patients with acute coronary syndrome.
出处
《中国煤炭工业医学杂志》
2017年第11期1296-1300,共5页
Chinese Journal of Coal Industry Medicine
基金
2014年度河北省医学科学研究重点课题计划(编号:ZD20140474)
