摘要
在栀子及其复方质量控制研究的基础之上,分析栀子及其相关复方中主要成分环烯醚萜苷类、二萜色素类代表性化学成分的药代动力学,归纳、总结单体给药、药对配伍给药、复方给药等对栀子中有效成分药代动力学的影响。研究表明栀子及其复方的质量控制主要是针对单一或多指标成分的含量测定和指纹图谱,对质量控制的研究尚有欠缺。药代动力学研究目前涉及到栀子中个别单体成分,无法全面反映栀子的药代动力学特征。建议后续有必要将质量控制与中药化学-药理效应学-药代动力学相结合,采用多成分整合方法研究栀子的体内药代动力学行为,以期为该药材的临床使用提供有益参考。
On the basis of quality control of Gardeniae Fructus and its compound,pharmacokinetics of the representative chemical constituents in Gardeniae Fructus and its related compounds were analyzed,such as iridoid glycosides and diterpene pigments. This study summarizes the effects of the monomer administration,compatibility administration, compound administration on pharmacokinetics of active ingredients in Gardeniae Fructus. The results show that the quality control of Gardeniae Fructus and its compound is mainly aimed at the determination and fingerprint of single or multiple index components,but there is still a lack of research on quality control. Pharmacokinetic studies are concerned with the single components in Gardeniae Fructus,which can not reflect the pharmacokinetic characteristics of Gardeniae Fructus. Therefore,in order to provide a useful reference for the clinical use of Gardeniae Fructus,the author thinks that it is necessary to combine the quality control with Chinese medicine chemistry-pharmacological effects-pharmacokinetics and study its pharmacokinetics with multicomponent integration method.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2017年第24期208-216,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81473356
81173553)
国家"重大新药创制"科技重大专项(2014ZX09304307001)
国家发展和改革委员会
国家中医药管理局中药标准化项目(ZYBZH-Y-SH-38)
关键词
栀子
中药复方
质量控制
环烯醚萜苷类
药代动力学
药对
栀子苷
Gardeniae Fructus
traditional Chinese medicine compound
quality control
iridoidglycosides
pharmacokinetics
couplet medicines
geniposide
