摘要
青光眼是仅次于白内障的全球第二大致盲性眼病,细胞老化是导致青光眼眼压升高的最直接危险因素.眼压的形成与房水循环密切相关.房水外流通道细胞主要包括小梁网细胞和Schlemm管内皮细胞,其对维持正常眼压起关键作用.细胞老化可诱发房水动力学异常,从而引起眼压升高.其中小梁网细胞老化可能导致细胞固有僵硬度增大,自噬功能障碍,microRNA表达异常,线粒体功能障碍等,造成细胞功能障碍.Schlemm管内皮细胞老化则降低细胞的通透性,影响机械传感性,干扰内皮型一氧化氮合酶的信号传导通路,导致房水外流阻力增大,从而引起眼压升高.本文将针对小梁网细胞和Schlemm管内皮细胞老化引起的房水动力学异常与青光眼关系的研究进展进行综述,以期为临床研究提供参考.
Glaucoma is the second leading cause of blindness in the world next to cataract. Aging is a strong risk factor leading to elevated intraocular pressure （IOP）. IOP is associated with aqueous humor circulation. Trabecular meshwork cells and Schlemm canal endothelial cells, which form the conventional outflow pathway, play an important role in maintaining the IOP. Cell senescence induces abnormalities of the aqueous humor dynamics, leading to elevated IOP. Trabecular meshwork cells cause increased intrinsic stiffness, autophagy dysfunction,abnormal expression of microRNA and mitochondrial dysfunction with senescence. The senescence of Schlemm canal endothelial cells decreases cell permeability and mechanotransduction and disrupts the endothelial nitric oxide synthase signaling pathway. The changes will increase aqueous humor outflow resistance and elevate IOP. This review discusses how cell senescence induces aqueous humor dynamics abnormalities and the relation with glaucoma.
出处
《中华眼科杂志》
CSCD
北大核心
2017年第11期868-873,共6页
Chinese Journal of Ophthalmology
基金
国家自然科学基金（81371015）
上海市卫生局青年杰出科学家计划（XYQ2013083）
