摘要
目的 比较视网膜断层扫描仪（HRT-Ⅱ）与相干光断层成像（HRA-OCT）在鉴别正常眼和视野前青光眼中的临床价值.方法 对33例视野前青光眼患者（视野前青光眼组）和37例健康对照者（对照组）行HRT-Ⅱ及HRA-OCT检查,比较两组视盘面积、视杯面积、盘沿面积、视杯容积、盘沿容积、杯盘面积比、线性杯盘比、视杯平均深度、最大视杯深度、视杯形态、轮廓线高度变化,并绘制受试者操作特征（ROC）曲线,通过计算曲线下面积（AUC）,并设定特异性为≥80％和≥95％,寻找HRT-Ⅱ及HRA-OCT对视野前青光眼的最佳诊断指标.结果 视野前青光眼组与对照组HRT-Ⅱ除视盘面积、轮廓线高度变化比较差异无统计学意义（P＞0.05）,其他各参数比较,对视野前青光眼有诊断意义（均P＜0.05）;66.7％的参数AUC＞0.800;58.3％的参数AUC＞0.900.HRA-OCT除鼻侧神经纤维层厚度（P＞0.05）外,其他参数对视野前青光眼有诊断意义（均P＜0.05）;66.7％的参数AUC＞0.800;33.3％的参数AUC＞0.900.HRT-Ⅱ对于视野前青光眼的最佳诊断参数杯盘面积比（AUC=0.984）与HRA-OCT的最佳诊断参数平均神经纤维层厚度（AUC=0.940）的敏感性及特异性差异均无统计学意义（P＞0.05）.结论 HRT-Ⅱ与HRA OCT两种仪器均能够较好地反映视野前青光眼患者视盘及其周围视网膜神经纤维层损害;对视野前青光眼诊断准确度较高;对于视野前青光眼的诊断敏感性及特异性相近.
Objective To compare the clinical value of Heidelberg retinal tomography （HRT-Ⅱ） and Heidelberg optical coherence tomography （HRA OCT） in discriminating healthy eyes and pre-perimetric glaucoma eyes.Methods A total of 33 patients with pre-perimetric glaucoma and 37 healthy subjects were included in this study.All individuals underwent imaging tests with HRT-Ⅱ and HRA OCT within 1-month period.ANOVA and Kruskal-Wallis test were used to compare all of the parameters from HRT-Ⅱ and HRA-OCT between pre-perimetric glaucoma eyes and normal eyes.Receiver operating characteristic curves （ROC） were calculated for all of the parameters to seek the best discriminant point of each instrument between pre-perinmetric glaucoma and healthy eyes.Results Statistically significant differences were found in most of the HRT-Ⅱ parameters except for disc area and height variation contour between pre-perimetric glaucomatous eyes and normal eyes （all P〈0.05）,which showed that most of the HRT-Ⅱ parameters were capable of diagnosing preperimetic glaucoma except for the disc area and height variation contour （all P〈0.05）.66.7% of the areas under the receiver operating characteristic curves （AUC） from HRT-Ⅱ parameters were larger than 0.800 and 58.3% of the AUC were larger than 0.900.Statistically significant differences were found in most of the HRA-OCT parameters except for the nasal retinal nerve fiber layer （RNFL）thickness between pre-perimetric glaucoma eyes and normal eyes （all P〈0.05）,which showed that most of the HRA-OCT parameters were capable of diagnosing pre-perimetic glaucoma except for the nasal RNFL thickness （all P〈0.05）.66.7% of the AUC from HRA-OCT parameters were larger than 0.800 and 33.3 % of the AUC were larger than 0.900.No statistically significant difference was found between the AUC for the best parameter diagnosing pre-perimetic glaucoma from HRT Ⅱ （cup/disk area ratio,AUC =0.984） and HRA OCT （average RNFL thickness,AUC =0.940）.No Statistically signi
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2015年第4期416-420,共5页
Chinese Journal of Geriatrics
基金
北京医院青年课题（BJ201284）
关键词
视网膜
视野
青光眼
Retina
Visual fields
Glaucoma
