摘要
目的探讨汉族人群原发性开角型青光眼(POAG)CDKN2B基因rs1063192位点基因型分布及本病与该基因位点多态性的关系。方法选取2019年5月至2021年5年江苏省海安市人民医院(以下简称“我院”)收治的98例汉族人群POAG患者为研究组,比较不同病理特征患者CDKN2B基因rs1063192位点基因型分布情况。另选取我院同期体检健康者92名作为对照组,比较研究组与对照组CDKN2B基因rs1063192位点基因型分布差异,分析CDKN2B基因rs1063192位点基因型与汉族人群POAG发病的关系。结果不同年龄、青光眼家族史情况、合并高血压情况的POAG患者CDKN2B基因rs1063192位点基因型分布比较,差异均有统计学意义(P<0.05)。两组基因型分布均符合Hardy-Weinberg遗传平衡检验(P>0.05)。研究组CDKN2B基因rs1063192位点GG、AG基因型频率高于对照组,G等位基因型频率高于对照组(P<0.05)。携带GG基因型汉族人群POAG发病风险是携带AA汉族人群的3.177倍,携带G等位基因汉族人群POAG发病风险是携带A等位基因汉族人群的2.751倍(P<0.05)。结论CDKN2B基因rs1063192位点GG基因型和G等位基因可能与汉族人群POAG发病有关,可增加汉族人群POAG发病风险。
Objective To investigate the genotype distribution of CDKN2B gene rs1063192 locus in primary open-angle glaucoma(POAG)in the Han nationality and POAG relationship with the polymorphism of the genetic locus.Methods A total of 98 patients with POAG from Han nationality admitted to Haian People’s Hospital,Jiangsu Province(hereinafter referred to as“our hospital”)from May 2019 to 2021 were selected as the study group.The genotype distribution of CDKN2B gene rs1063192 locus in patients with different pathological characteristics was compared.Another 92 healthy subjects in our hospital at the same period were selected as the control group,the difference in genotype distribution of CDKN2B gene rs1063192 locus between the study group and the control group was compared.The relationship between rs1063192 genotype of CDKN2B gene and POAG in the Han nationality was analyzed.Results There were statistically significant differences in genotype distribution of CDKN2B gene rs1063192 locus in POAG patients with different ages,family history of glaucoma,and hypertension(P<0.05).The genotypes of the two groups were consistent with Hardy-Weinberg genetic balance test(P>0.05).The frequency of GG and AG genotypes at CDKN2B gene rs1063192 locus in study group were higher than that in control group,and the frequency of G allele was higher than that in control group(P<0.05).The risk of POAG in the Han nationality with GG genotype was 3.177 times of that in the Han nationality with AA genotype,and the risk of POAG in the Han nationality with G allele was 2.751 times of that in the Han nationality with A allele(P<0.05).Conclusion GG genotype and G allele of CDKN2B gene rs1063192 locus may be associated with the incidence of POAG in the Han nationality,and may increase the risk of POAG in the Han nationality.
作者
陆宇清
王玲
徐静
李乐超
蔡鑫
LU Yuqing;WANG Ling;XU Jing;LI Lechao;CAI Xin(Department of Ophtalmology,Haian People’s Hospital,Jiangsu Province,Haian226600,China;Department of Ophtalmology,Wuxi People’s Hospital,Jiangsu Province,Wuxi214023,China;Department of Ophtalmology,Suzhou Ninth People’s Hospital,Jiangsu Province,Suzhou215000,China;Department of Neurology,Xuzhou Central Hospital,Jiangsu Province,Xuzhou221000,China)
出处
《中国医药导报》
CAS
2022年第24期107-110,共4页
China Medical Herald
基金
江苏省自然科学基金项目(BK20210095)。
