摘要
生殖支原体是男女生殖道及直肠感染的重要性病病原体，可通过黏附上皮细胞激发宿主的免疫反应，导致局部炎症。近年来，随着大环内酯类耐药菌株的广泛流行，早期使用阿奇霉素治疗生殖支原体感染的疗效明显下降。喹诺酮类的莫西沙星等可提高生殖支原体感染的治愈率，然而随之而来的喹诺酮类耐药菌株的出现，其治疗失败病例开始出现。更为严重的是，已经出现对大环内酯及喹诺酮类同时耐药的多重耐药菌株的报道。多西环素、原始霉素等也可用于生殖支原体感染的治疗，但存在细菌清除率低或每天多次服药的不足，因此，有必要寻找新的治疗药物及更佳的治疗方案。
Mycoplasma genitalium is an important sexually transmitted pathogen which infects the reproductive tract and rectum of males and females. It can cause local inflammation by adhering to epithelial cells and activating the host immune response. In recent years, with the wide spread of macrolide- resistant strains, the efficacy of early use of azithromycin for the treatment of Mycoplasma genitalium infection has been obviously decreased. Quinolones such as moxifloxacin can increase the cure rate of Mycoplasma genitalium infection. However, with the emergence of quinolones-resistant strains, treatment failure cases have been reported. More seriously, there have been reports on muhidrug-resistant strains which are resistant to both macrolides and quinolones. Doxycycline and pristinamycin can also be used for the treatment of Mycoplasma genitalium infection, but there are some disadvantages of low bacterial clearance rate and multiple daily administration. Therefore, new drugs and better treatment approaches for Mwoplasma zenitalium infection are needed.
出处
《国际皮肤性病学杂志》
2017年第6期374-376,共3页
International Journal of Dermatology and Venereology
关键词
生殖支原体
微生物学现象
治疗应用
抗菌药
抗药性
Mycoplasma genitalium
Microbiological phenomena
Therapeutic uses
Anti-bacterial agents
Drug resistance
