摘要
目的:探讨人类免疫缺陷病毒(HIV)合并乙型肝炎病毒(HBV)感染对患者的免疫功能和肝功能的影响。方法:选取广州市第八人民医院2009年4月至2015年4月收治的已确诊Hl V阳性感染者266例,其中包括单纯HIV感染者220例,合并HBV感染者46例,选取同时期单纯HBV感染者50例,抽取血样比较分析3组患者CD4^+、CD8^+T淋巴细胞数,并进行肝功能检测,比较3组患者丙氨酸氨基转移酶(ALT)、天冬氨酸转移酶(AST)、总胆红素(TBIL)数值。结果:HIV合并HBV感染者CD8^+T淋巴细胞数明显高于单纯HIV感染者以及单纯HBV感染者,差异具有统计学意义(P<0.05),合并感染患者外周血CD4^+T淋巴细胞计数与单纯HIV患者比较,差异无统计学意义(P>0.05),两组均低于单纯HBV感染患者,差异具有统计学意义(P<0.05)。肝功能检测,合并组ALT、AST高于单纯HIV组,但低于单纯HBV组,差异具有统计学意义(P<0.05),3组TBIL比较,差异无统计学意义(P>0.05)。结论:HIV感染合并HBV感染能够增加机体的免疫应答,增加对机体的损害,同时也增加对肝脏的损害。
Objective liver function. Methods To research and discuss the effect of HIV combined with HBV infection on immune function and 266 cases were selected in our hospital from April April 2009 to 2015 has been diagnosed as HIV positive infection, including 220 cases of simple HIV infection, 46 cases of patients with HBV infection, select period with simple HBV infected with 50 cases, blood sampling comparative analysis three groups of patients with CD4＋ and CD8＋ T lymphocyte count, and liver function tests and compared three groups of patients with alanine aminotransferase （ALT）, aspartic acid shift enzyme （AST）, total bilirubin （TBIL） numerical. Results The number of CD8＋T lymphocytes in HIV complicated with HBV infection was significantly higher than that of HIV infected persons and those with simple HBV infection, the difference was significant statistically significant （P〈0.05）. The peripheral blood CD4＋T lymphocyte count in co-infected patients and HIV patients had not significantly different, there was no statistically significant difference （P〉0.05）. The two groups were lower than those of simple HBV infection, the difference was significant statistically significant （P〈0.05）. After liver function test, the ALT, AST of combined group was significantly higher than the simple HIV group, but lower than the simple HBV group, the difference was significant statistically significant （P〈0.05）. TBIL of three groups were not significantly different, there was no statistically significant difference （P〉0.05）. Conclusion HIV infection with HBV infection can increase the body＇s immune response, increasing the damage to the body, but also increase the damage to liver.
出处
《深圳中西医结合杂志》
2016年第16期3-5,共3页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
广东省自筹经费类科技计划项目资助课题(20140213)
关键词
人类免疫缺陷性病毒
乙型肝炎病毒感染
艾滋病
免疫功能
肝功能
Human immunodeficiency virus
Hepatitis B virus infection
Cataract surgury rate
Immune function
Liver function
