摘要
目的研究720例孕早期自然流产(SA)胚胎的异常核型临床情况。方法回顾性分析2013年1月-2016年12月在西北妇女儿童医院就诊的720例孕早期SA患者。记录患者的相关数据信息并统计分析,主要分析SA胚胎核型及SA胚胎非整倍体的异常核型,患者流产年龄及流产次数与胚胎核型的关系。结果 SA胚胎异常核型者的比例为58.61%,SA胚胎正常核型为41.39%。其中异常核型以非整倍体为主,占39.72%。SA胚胎非整倍体的异常核型中,+16型62例,占21.68%;+22型44例,占15.38%;(45,X)型40例,占13.99%。≥36岁患者的胚胎异常核型及非整倍体的比例均明显高于年龄<36岁者,而≥36岁患者正常核型的比例明显低于<36岁者,差异有统计学意义(均P<0.05)。>2次流产患者的异常核型和染色体的结构异常比例明显高于≤2次流产者,非整倍体的比例明显低于≤2次流产者,差异有统计学意义(均P<0.05)。结论 SA以胚胎异常核型为主,此类异常核型主要是非整倍体的核型异常,且患者的流产年龄和流产次数均与胚胎核型有关。
Objective To study the clinical situation of embryo abnormal karyotype in 720 cases of early spontaneous abortion （ SA ）. Methods We retrospectively analyzed 720 early SA patients hospitalized in Northwest Women＇s and Children% Hospital from January 2013 to December 2016. The related data of the patients were recorded, and then performed statistical analysis of karyotypes from SA embryos, abnormal karyotypes from aneuploid embryos in SA and the relationship between abortion age, abortion frequency and embryo karyotype. Results The proportion of abnormal karyotypes from SA embryos was 58.61%, while that of normal karyotypes from SA embryos was 41.39%. The aneuploid was the most common type of abnormal karyotypes, accounting for 39.72%. Among abnormal karyotypes from aneuploid embryos in SA, ＋ 16 type was identified in 62 （21.68%） cases, ＋22 type in 44 （15.38%） cases and （45, X） type in 40 （13.99%） cases. The proportions of abnormal embryo karyotypes and aneuploid were both significantly higher in patieuts aged ≥ 36 years than in patients aged 〈36 years, while the proportion of normal karyotypc was significantly lower in patients aged ≥ 36 years than in patients aged 〈36 years, showing statistically significant differences （ all P 〈0.05 ）. The proportions of abnormal karyotypcs and chromosome structure abnormality were significantly higher in patients with SA for 〉 2 times than in patients with SA for ≤ 2 times, while the proportion of aneuploid was significantly lower in patients with SA for 〉 2 times than in patients with SA for ≤ 2 times, with statistically significant differences （ all P〈0.05 ）. Conclusion The embryo abnormal karyotypes are found to represent the main cause of SA, and the abnormal karyotype of aneuploid is the commo- nest; moreover, the patients＇ abortion age and abortion frequency are related to the embryo karyotypes.
出处
《实用预防医学》
CAS
2017年第12期1485-1488,共4页
Practical Preventive Medicine
基金
陕西省青年科技新星计划项目(2016KJXX-23)
关键词
孕早期
自然流产
胚胎
异常核型
early pregnancy
spontaneous abortion
embryo
abnormal karyotype
