摘要
目的分析染色体异染色质区增加与生殖相关的临床效应。方法对6958例生殖异常患者通过取外周血淋巴细胞培养,显带进行染色体核型分析。结果检出染色体异染色质区增加196例,占被检患者的2.82%。结论染色体异染色质区增加导致自然流产、不孕不育、死胎、闭经、生殖器发育异常、少弱及无精子症等遗传效应,在遗传咨询中应引起足够的重视,对临床诊治工作有重要意义。
Objective： Analysis of chromosome heterochromatin area increased and reproductive - related clinical effects. Methods： of 6958 cases of reproductive abnormalities in peripheral blood lymphocyte culture by taking, banding for karyotype analysis. The results detected chromosome heterochromatin area increased 196 cases, accounting for 2. 82% of patients were seized. Conclusion： chromosome heterochromatin region led to increased spontaneous abortion, infertility, stillbirth, amenorrhea, genital abnormalities, and no less fine psychosis weak genetic effects, in genetic counseling should be taken seriously enough, the clinical diagnosis and treatment are important significance.
出处
《中国优生与遗传杂志》
2011年第12期43-44,37,共3页
Chinese Journal of Birth Health & Heredity
关键词
染色体
异染色质区增加
细胞遗传学
Chromosome
Heterochromatin region increased
Cytogenetics
