摘要
目的采用随机对照试验评估含铋剂四联疗法10 d和14 d疗程对幽门螺杆菌(H.pylori)的根除疗效。方法纳入2016年1月至12月第三军医大学新桥医院240例确诊为H.pylori感染的患者,随机分成10 d治疗组(117例)和14 d治疗组(123例),分别予以10 d和14 d疗程的埃索美拉唑+铋剂+克拉霉素+阿莫西林四联治疗。停药4周后检测H.pylori根除效果并记录不良反应。结果 240例患者219例完成随访,2组患者基线临床资料具有可比性(P>0.05)。按意向性(ITT)分析,10 d及14 d治疗组根除率分别为77.8%(91/117),76.4%(94/123);按符合方案(PP)分析,10 d及14 d治疗组根除率分别为85.8%(91/106),83.2%(94/113),2组患者根除率比较,差异无统计学意义(P>0.05)。2组不良事件发生率分别为7.7%(9/117)和9.8%(12/123),2组比较差异无统计学意义(P>0.05)。结论含铋剂四联疗法10 d与14 d疗程H.pylori根除效果相当,10 d疗程具有更高的效价比。
Objective To compare the efficacy of bismuth-containing quadruple therapy on H. pylori eradication for 10 days versus 14days in a randomized controlled trial. Methods A total of 240 patients diagnosed with H. pylori infection were randomly assigned to two groups：treated with esomeprazole, bismuth,clarithromycin and amoxicillin for 10 days（n = 1 1 7 ） and for 14 days（ n = 123 ） . Eradication was defined by rapid urease test or 13C-urea breath test at 4 weeks after drug withdrawal. Results A total of 21/ patients were complete the tri-al. Intention-to-treat（ ITT ） analysis showed that the eradication rate of 10 and 14 days were 77. 8% （91/117 ） and 76. 4% （94/123） respec-tively. Per protocol（PP ） analysis indicated that the eradication rate of 10 and 14 days were 85. 8% （91/106 ） and 83.2% （94/113 ） respec-tively. There was no statistically significant differences bet^veen the two groups（P 〉0. 05）. The incidence of adverse evand 9. 8% （ 12/123 ）, respectively. There was no significant difference（ P 〉 0. 05 ） . Conclusion The eradication rate of bismuth-containing quadruple therapy for 10 days and 14 days were essentially identical, bismuth-containing quadruple therapy forratio.
作者
王涛
廖忠莉
杨丽
程姮
郭红
WANG Tao;LIAO Zhong-li;YANG Li;CHENG Heng;GUO Hoog(Department of Gastroenterology , Xinqiao Hospital , ThirdMilitary Medical University ,Chongqing 400037, Chin)
出处
《局解手术学杂志》
2017年第11期831-833,共3页
Journal of Regional Anatomy and Operative Surgery
关键词
幽门螺杆菌
含铋剂四联疗法
根除率
helicobacter pylori
bismuth-containing quadruple therapy
eradication rate
