摘要
目的:分析益生菌辅助治疗对Hp阳性患者胃肠道症状及肠道微生物群分布情况的影响。方法:选取2020年2月-2021年1月武汉市江夏区纸坊街社区卫生服务中心与北部战区总医院收治的80例Hp阳性患者。以随机数字分配法分为单纯治疗组和益生菌辅助治疗组,每组40例。单纯治疗组口服泮托拉唑、阿莫西林、呋喃唑酮、胶体果胶铋,益生菌辅助治疗组在单纯治疗组的基础上加用丁酸梭菌,两组均治疗28 d。比较两组治疗28 d后Hp根除率,治疗前及治疗28 d后胃肠道症状、粪便细菌菌群数量。结果:治疗28 d后,单纯治疗组根除率为47.50%,与益生菌辅助治疗组(60.00%)比较,差异无统计学意义(P>0.05)。与治疗前相比,治疗28 d后,益生菌辅助治疗组硬便、反酸、腹痛、肠鸣评分降低,且低于单纯治疗组,差异有统计学意义(P<0.05)。与治疗前相比,治疗28 d后,单纯治疗组粪便乳杆菌属、肠球菌属、梭菌属、疣微菌属菌群数量降低(P<0.05),益生菌辅助治疗组粪便肠球菌属、疣微菌属菌群数量降低(P<0.05),益生菌辅助治疗组粪便乳杆菌属、梭菌属菌群数量高于单纯治疗组(P<0.05)。结论:益生菌辅助治疗Hp阳性患者,可缓解其胃肠道症状,改善肠道微生物群分布情况。
Objective:To analyze the effect of adjuvant probiotic treatment on the gastrointestinal symptoms and the distribution of intestinal microbiota in Hp-positive patients.Method:A total of 80 Hp positive patients admitted to Wuhan Jiangxia District Zhifang Street Community Health Service Center and Northern Theater Command General Hospital from February 2020 to January 2021 were selected,and divided into the single treatment group and the probiotics adjuvant treatment group by random number allocation method,40 cases in each group.Pantoprazole,Amoxicillin,Furazolidone and Colloid Pectin Bismuth were taken orally in the single treatment group,and Clostridium Butyricum was added in the probiotics adjuvant treatment group on the basis of the single treatment group.Both groups were treated for 28 d.The rate of Hp eradication after 28 d of treatment,the gastrointestinal symptom and fecal bacterial flora number before and after 28 d of treatment were compared between the two groups.Result:After 28 d of treatment,the eradication rate of the single treatment group was 47.50%,which was not statistically significant compared with 60.00%in the probiotic adjuvant treatment group(P>0.05).Compared with before treatment,after 28 d of treatment,the scores of hard stools,acid reflux,abdominal pain and bowel noise in the probiotics adjuvant treatment group were lower,and lower than the single treatment group,the differences were statistically significant(P<0.05).Compared with before treatment,after 28 d of treatment,the number of fecal Lactobacillus,Enterococcus,Clostridium and Verrucomicrobia in the single treatment group decreased(P<0.05),the number of fecal Enterococcus and Verrucomicrobia in the probiotics adjuvant treatment group decreased(P<0.05),while the numbers of Lactobacillus and Clostridium in the probiotics adjuvant treatment group were higher than the single treatment group(P<0.05).Conclusion:The adjuvant treatment of probiotics could relieve the gastrointestinal symptoms and improve the distribution of intestinal microb
作者
黄运梅
曹旭
HUANG Yunmei;CAO Xu(Wuhan Jiangxia District Zhifang Street Community Health Service Center,Wuhan 430200,China;不详)
出处
《中外医学研究》
2022年第12期98-101,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
幽门螺杆菌
益生菌
肠道微生物群
胃肠道症状
Helicobacter pylori
Probiotics
Gut microbiota
Gastrointestinal symptoms
