摘要
目的探讨康莱特注射液治疗晚期胰腺癌的效果及对患者免疫功能的影响。方法采用回顾性研究方法,选择晚期胰腺癌患者72例作为研究对象,根据随机平行数字信封法分为观察组与对照组,各36例。对照组给予常规放化疗治疗,观察组在对照组治疗的基础上给予康莱特注射液治疗。2组都治疗观察2个疗程,记录预后与免疫指标变化情况。结果治疗后观察组与对照组的总有效率分别为77.8%和44.4%,观察组的总有效率明显高于对照组(P<0.05)。观察组与对照组治疗期间的血像反应与消化道反应情况对比,无明显差异(P>0.05)。治疗后观察组与对照组的CA19-9与CEA值明显低于治疗前(P<0.05),同时治疗后观察组的CA19-9与CEA值也低于对照组(P<0.05)。治疗后观察组的CD3^+值明显上升,而CD4^+值明显降低,较治疗前差异均明显(P<0.05),而对照组治疗前后的CD3^+、CD4^+值差异无统计学意义(P>0.05)。结论康莱特注射液治疗晚期胰腺癌能提高治疗效果,降低肿瘤标志物的表达,且不会增加不良反应,其作用机制与提高免疫力有关。
Objective To investigate the effect of Kanglaite injection on immune target in patients with advanced pancreatic cancer Methods Used a retrospective study,72 cases of advanced pancreatic cancer patients were selected as the re- search object, all the cases were. divided into the observation group and the control group, with 36 cases in each group. The control group received conventional radiotherapy therapy, the observation group was given the Kanglaite injection treatment based on the control group, the prognosis and immune index changes were recorded in the 2 groups. Results After treatment, the total effective rate of the observation group and the control group were 77.8% and 44.4% ,respectively. The total effective rate of the observation group was significantly higher than that of the control group （ P 〈0.05 ） .There were no significant difference between the ob- servation group and the control group during the treatment of hemogram and gastrointestinal reaction （P 〉 0.05 ）. After treatment, the CA19-9 and CEA values in the observation group and the control group were significantly lower than before treatment （P 〈 0.05 ）, while the observation group after treatment were also lower than those of the control group （ P 〈 0.05 ）. After treatment, the CD3 ~ value of the observation group was significantly increased, while the CD4 ~ value significantly reduced, compared with before treatment, the difference was significant （P 〈 0.05 ）, but there were no significant difference between the CD3＋ and CD4＋ values before and after treatment in the control group （P 〉 0.05）. Conclusion Kanglaite injection can improve the therapeutic effect in the treatment of advanced pancreatic cancer, reduce the expression of tumor markers, and does not increase the adverse effect, its mechanism may be related to improve the immunity.
出处
《实用癌症杂志》
2017年第11期1863-1866,共4页
The Practical Journal of Cancer
关键词
康莱特注射液
晚期胰腺癌
免疫功能
肿瘤标志物
不良反应
Kanglaite injection
Advanced pancreatic cancer
Immune function
Tumor marker
Adverse reaction
