摘要
目的:探讨磁共振动态增强扫描(DCE-MRI)定量参数和表观扩散系数(ADC)对前列腺癌的临床诊断价值及ADC与血清前列腺特异抗原(PSA)、α-甲基酰基辅酶A消旋酶(P504S)的相关性。方法:选取本院2012年4月至2015年7月确诊为前列腺病变的60例患者为研究对象,其中前列腺癌32例(前列腺癌组),前列腺增生28例(前列腺增生组)。所有患者均进行常规磁共振检查、DCE-MRI及扩散加权成像(DWI)检查。同时选取30例健康者(正常组)进行常规磁共振检查作为对照。比较3组患者的DCE-MRI定量参数、DWI信号强度值和ADC值,血清PSA、P504S表达情况以及ADC与PSA、P504S的相关性。结果:3组患者的DCE-MRI定量参数相比,前列腺癌组最高,正常组最低,3组差异显著(P<0.05)。前列腺癌患者随着扩散敏感系数(b值)的升高,DWI信号强度增加,ADC值则表现为低信号;前列腺增生组随着b值的升高,DWI信号强度变化不显著,而正常组则随着b值的升高,DWI信号强度降低,且前列腺增生组和正常组的ADC值均表现为高信号,3组差异显著(P<0.05)。前列腺癌组和前列腺增生组的患者PSA表达水平无显著差异(P>0.05),而P504S表达前列腺癌组显著高于前列腺增生组(P<0.05)。相关性分析显示ADC值与PSA、P504S均呈显著负相关(P<0.05)。结论:DCE-MRI可用于前列腺癌的诊断及鉴别;ADC值与前列腺的特异性抗原PSA、P504S呈显著负相关,其测量有助于对前列腺癌的生物学特性进行初步评估。
Objective： To investigate the clinical diagnosis value of DCE-MRI quantitative parameters and ADC values in patients with prostate cancer and the correlations with serum PSA and P504 S.Methods： 60 patients with prostate cancer in our hospital from Apr,2012 to Jul,2015 were selected as the research objects,including 32 cases of prostate cancer （prostate cancer group）,28 patients with benign prostatic hyperplasia （BPH group）.All patients were examined by routine MRI,DCE-MRI and DWI.At the same time,30 healthy people were selected as the control group.DCE-MRI quantitative parameters,DWI signal intensity,ADC values,the expressions of serum PSA,P504 S,and the correlations between ADC and PSA,P504 S were compared.Results： DCE-MRI quantitative parameters in the 3 groups were compared,there was significant differences among 3 groups （P〈0.05）.With the increase of diffusion sensitive coefficient （b value）,DWI signal intensity increased and ADC value showed low signal in patients with prostate cancer.In BPH group,with the increase of b value,the signal intensity of DWI did not change significantly,while in normal group,the signal intensity of DWI decreased with the increase of b value,and the ADC values of BPH group and normal group showed high signal,there were significant differences in the 3 groups （P〈0.05）.There was no significant difference on the expression of PSA between the prostate cancer group and the BPH group （P〉0.05）,while the expression of P504 S in prostate cancer group was significantly higher than that in the BPH group （P〈0.05）.Correlation analysis showed that ADC value was negatively correlated with PSA and P504 S （P〈0.05）.Conclusion： DCE-MRI can be used in the diagnosis and differentiation of prostate cancer.The ADC value was negatively correlated with prostate specific antigen PSA and P504 S,it is helpful to assess the biological characteristics of prostate cancer.
出处
《现代医学》
2017年第9期1266-1270,共5页
Modern Medical Journal
关键词
磁共振动态增强扫描
表观扩散系数
前列腺癌
dynamic contrast-enhanced magnetic resonance imaging
apparent diffusion coefficient
prostate cancer
