摘要
目的观察中药内服联合1 mg非那雄胺治疗男性雄激素性秃发(AGA)的疗效。方法青年男性AGA患者共70例,随机分为2组,分别予口服1 mg非那雄胺联合中药、单纯口服中药治疗,观察2组治疗3、6个月时头皮局部症状(油腻、瘙痒、头屑)、毛发生长改善情况。结果中药内服联合1 mg非那雄胺治疗湿热青年男性型脱发28例(剔除脱落7例),止脱率为89.3%,有效率为82.2%;对照组收录27例(剔除脱落8例),止脱率为85.2%,有效率为55.6%,治疗组止脱率较对照组差异无统计学意义(P>0.05),治疗组的有效率要高于对照组,差异有统计学意义(P<0.05);经6个月治疗后,治疗组与对照组组内头皮油腻、瘙痒、头屑情况较治疗前均有明显好转,差异有统计学意义(P<0.05),2组间头发油腻、头屑、头皮瘙痒情况治疗后差异无统计学意义(P>0.05);治疗组脱落率为20.0%,对照组脱落率为22.86%,低于单纯口服非那雄胺脱落率;秃发的疗效同秃发的严重程度呈负相关性。结论单纯中药内服可显著改善头皮局部症状(油腻、头屑及瘙痒),毛发生长改善较慢;中药内服联合1 mg非那雄胺治疗AGA可较快的控制秃发情况,缓解头皮症状,提高患者依从性,降低脱落率,提高疗效。
Objective In order to observe the efficacy of traditional Chinese medicine TCM combined with finasteride 1mgin the treatment of male androgenic alopecia AGA . Methods Seventy young males AGA patients were randomly divided into treatment group and control group. The treatment group was taken TCM with finasteride, and the control group was takenTCM only. The efficacy of scalp symptoms fat, itching, scurf and hair growth were evaluated at third and sixth month aftertreatment. After six months, because some patients did not finish the follow up, seven cases in the treatment groupand eight cases in the control group were dropped out. The total effective rate of treatment group 28 cases, 82.2% was obviouslyhigher than that of the control group 27 cases, 55.6%, （P〈0.05） . The control rate of treatment group was 89.3%, and that ofthe control group was 85.2%, there was no statistical significance in both groups （P〉0.05） . Meanwhile the scalp localsymptoms fat, itching, scurf were obviously improved in both two groups （P〈0.05） , and there was no significant differencebetween the two groups （P〉0.05） . The deprivation rate of the treatment group was 20%, and that of the control group was22.86%. Both two groups were lower than oral finasteride. The effective rate was negatively correlation with the severity of thealopecia. Internal administration of herbs can obviously improve the scalp local symptoms fat, itching, scurf ,and promote hair growth slowly. The combined treatment can control baldness, promote hair growth and improve the symptomsof the scalp faster, so that it can reduce the rate of exfoliation, enhance adherence and improve efficacy.
出处
《中国中西医结合皮肤性病学杂志》
CAS
2017年第5期405-408,共4页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
基金
基金项目:浙江省中医院余氏外科流派工作室(编号:2016-LP-05)
关键词
中医药
非那雄胺
雄激素性秃发
疗效
依从性
Traditional Chinese medicine
Finasteride
Androgenic alopecia
Curative effect
Compliance
