摘要
目的:观察血府逐瘀汤合十味温胆汤加减中西医结合用于治疗冠心病合并抑郁焦虑的临床疗效。方法:选择我院收治的冠心病合并抑郁焦虑患者100例,按照随机数字表法分为对照组和观察组。对照组患者给予常规药物治疗及心理干预辅导;观察组在此基础上联合血府逐瘀汤及十味温胆汤加减治疗。结果:观察组的总有效率为96.00%(95%CI=85.80%~99.48%),对照组为84.00%(95%CI=73.84%~94.16%),两组综合疗效比较(u=1.205 5,P=0.228 0),差异未达到显著性意义;观察组心电图综合疗效优于对照组(u=3.103 8,P<0.01);与对照组比较,观察组可降低HAMD、HAMA评分参数(P<0.01)。结论:采用血府逐瘀汤联合十味温胆汤中西医结合疗法治疗冠心病合并抑郁焦虑的临床疗效优于西医治疗的证据不够充分,其收益为OR=0.22(95%CI=0.04~1.09),NNT=8(95%CI=4.21~416.67)。
Objective：To observe the clinical effect of Xuefu Zhuyu decoction and modified Shiwei Wendan de- coction （integrated traditional Chinese and western medicine） on coronary heart disease with depression and anxie- ty. Methods ：100 cases of selected patients with coronary heart disease with depression and anxiety treated in our hospital were divided randomly into observation group and control group. The control group was treated with con- ventional medicine and psychological intervention counseling;while the observation group was treated with Xuefu Zhuyu decoction and modified Shiwei Wendan decoction on the basis of control group. Results： The total effective rate of observation group was 96.00% （95% CI = 85.80% to 99.48% ） ,while the total effective rate of control group was 84.00% （95% CI =73.84% to 94.16% ）. Compared the comprehensive effect between two groups（ U = 1. 205 5, P = 0.228 0）, the difference did not reach significant significance. The electrocardiogram and com- prehensive effect of observation group were better than those of control group（ U =3. 103 8, P 〈0. 01 ）. Compared with control group ,the observation group could decrease the score parameters HAMD, HAMA （P 〈 0.01 ）. Con- clusion ： The clinical effect of Xuefu Zhuyu decoction and modified Shiwei Wendan decoction （ integrated traditional Chinese and western medicine） on coronary heart disease with depression and anxiety is better than that of simple western medicine,but the evidence is insufficient. Its benefit is OR =0.22 （95% CI =0.04 to 1.09）, NNT =8 （95% CI =4.21-416.67）.
出处
《山西中医》
2017年第10期23-25,共3页
Shanxi Journal of Traditional Chinese Medicine
关键词
冠心病心绞痛合并抑郁焦虑
血府逐瘀汤
十味温胆汤
中西医结合疗法
angina pectoris of coronary heart disease, depression and anxiety, Xuefu Zhuyu decoction, ShiweiWendan decoction, therapy of integrated traditional Chinese and western medicine
