摘要
目的了解男性HIV单阳家庭中阴性女配偶基于不同性目的暴露前预防用药（PREP）接受意愿及其影响因素。方法采用整群随机抽样的方法，以广西壮族自治区贵港市、桂平市、平南县HIV单阳家庭中的阴性女配偶作为调查对象，2013年6月至2016年11月通过现有疫情数据库进行招募，利用自行设计的问卷进行面对面调查，内容包括调查对象的=般情况和PrEP接受意愿。统计学处理采用）[“检验和Logistic回归分析。结果共获得有效问卷526份。基于生理性目的PrEP接受率为66．9％（352／526），基于生育性目的PrEP接受率为93．3％（491／526），比较差异有统计学意义（Х^2=139．48。P％0．01）。不接受PrEP的原因主要为担心其安全性、有效性和保密性得不到保障以及感染自评危险性小。Logistic回归分析显示，基于生理性目的PrEP接受意愿的影响因素包括PrEP认知（OR=0．70，P=0．014）、固定性伴侣数量（OR=0．55，P％0．01）、性行为频率（OR=1．33，P=0．016）、安全套使用意愿（OR=0．16，P〈O．01）、感染危险自评（OR=0．22，P〈0．01）、男方病毒载量（OR=1．25，P=0．035）、男方CD4^＋T淋巴细胞计数（OR=0．37，P〈0．01）、男方用药与否（OR=1．59，P〈0．01）。基于生育性目的PrEP接受意愿的影响因素包括有无子女（OR—1.70，P〈0．01）、PrEP认知（OR=0．72，P=0．026）、安全套使用意愿（OR=0．18，P％0．01）、感染危险自评（OR=0．14，P〈0．01）、男方CD4^＋T淋巴细胞计数（OR=0．45，P％0．01）。结论HIV单阳家庭阴性女配偶基于生育性目的PrEP接受意愿明显高于生理性目的，在围孕期HIV单阳家庭中开展PrEP临床试验更具有可行性，其影响因素主要与个人行为特征及其配偶感染特征有关，与=般社会人口学特征无关。
Objective To study the acceptability and associated factors of pre-exposure prophylaxis （PREP） based on different sexual purpose among human immunodeficiency virus （HIV） male serodiscordant couples. Methods HIV-negative female spouses of HIV-positive male in Guigang, Gulping and Pingnan county in Guangxi Zhuang Autonomous Region were recruited by the existing epidemic database and the method of cluster random sampling. A face-to-face questionnaire survey was conducted during June 2013 to November 2016. Information including the general condition and acceptability of PrEP was surveyed. Z2 test and Logistic regression were used to analyze the data. Results A total of 526 qualified questionnaires were collected. The intention rate of PrEP based on physiological sexual purpose was 66.9% （352/526）, the intention rate of PrEP based on fertility purpose was 93. 3% （491/526）. The difference was statistically significant （Х^22 = 139.48, P〈0.01）. The reasons of refusal included worrying about its safety, effectiveness, poor confidentiality and low self-assessment risk of infection. Logistic analysis showed that the associated factors of the intention rate of PrEP based on physiological sexual purpose included cognition of PrEP （OR=0.70, P=0. 014）, the number of lifetime partners （OR^0. 55, P〈0.01）, frequency of sexual behavior （OR=I. 33, P=0. 016）, willingness of condom use （OR=0. 16, P（0.01）, infection risk self-assessment （OR = 0. 22, P〈0. 01）, male viral load （OR= 1. 25, P= 0.0S;5）, male CD4~ T lymphocyte count （OR=0.37, P〈0. 01） and male usefulness of medication or not （OR= 1. 59, P〈0.01）. The influencing factors of the intention rate of PrEP based on physiological sexual purpose included with or without children （OR=1.70, P〈0.01）, cognition of PrEP （OR〈0. 72, P=0. 026）, willingness of using condom （OR=0.18, P〈0.01）, infection risk self-assessment （OR= 0.14, P〈0. 01） and male CD4^＋ T lymphocyte count （OR--0. 45, P〈0. 01）. C
出处
《中华传染病杂志》
CSCD
北大核心
2017年第8期460-466,共7页
Chinese Journal of Infectious Diseases
